Activation of pyruvate dehydrogenase in perfused rat heart by dichloroacetate (Short Communication).

The Biochemical journal ·Vol. 134 ·No. 2 ·1973-06-00 ·Pages 651-3

Whitehouse S, Randle PJ

Abstract

The activity of pyruvate dehydrogenase was assayed in extracts of rat hearts perfused in vitro with media containing glucose and insulin+/-acetate+/-dichloroacetate. Dichloroacetate (100mum, 1mm or 10mm) increased the activity of pyruvate dehydrogenase in perfusions with glucose or glucose+acetate. Evidence is given that dichloroacetate may facilitate the conversion of pyruvate dehydrogenase from an inactive (phosphorylated) form into an active (dephosphorylated) form.

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Whitehouse S

Department of Biochemistry, Medical School, University of Bristol, University Walk, Bristol BS8 1TD, U.K.

Randle P J

References (9)

9 references, click to expand

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Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj1340651

Published

1973-06-00

Pages

651-3

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1177854

External Links

PubMed source DOI: 10.1042/bj1340651 PMC Full Text View journal details

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Activation of pyruvate dehydrogenase in perfused rat heart by dichloroacetate (Short Communication).

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