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PMID: 16742526 Published · ppublish English Journal Article

The C-terminal sequences of the heavy chains of human immunoglobulin G myeloma proteins of differing isotopes and allotypes.

The Biochemical journal ·Vol. 105 ·No. 3 ·1967-12-00 ·Pages 1019-28

Prahl JW

Abstract

The sequences of the C-terminal octadecapeptides obtained by cyanogen bromide cleavage of the gamma-chains of myeloma proteins of the four subclasses, and a urinary heavy-chain-disease protein, have been determined. Although the sequences were markedly homologous, unique replacements were identified that distinguished between the gamma(2b), gamma(2c) and gamma(2d) subclasses. The data are in accord with the postulated existence of four genetic loci or cistrons, these having arisen by the process of gene duplication.

Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Prahl J W
Department of Immunology, St Mary's Hospital Medical School, London, W. 2.
References (35)
35 references, click to expand
  1. Studies on the catabolism of gamma- G subunits and chains.
    J Immunol. 1965 Dec;95(6):1034-40 PMID: 4158797
  2. GM and INV factors in subclasses of human IgG.
    J Exp Med. 1965 Dec 1;122(6):1087-102 PMID: 4159034
  3. Relation between Gm(f) and the structure of the gamma-globulin molecule.
    Nature. 1965 Sep 4;207(5001):1099-101 PMID: 4160245
  4. The N- and c-terminal amino acid sequences of the heavy chain from a pathological human immunoglobulin IgG.
    Biochem J. 1966 May;99(2):356-66 PMID: 4161440
  5. Genetically determined antigen of the Ne subgroup of gamma-globulin: detection by precipitin analysis.
    Science. 1966 Nov 25;154(3752):1041-3 PMID: 4162154
  6. Structural studies of human gamma-G-myeloma proteins of different antigenic subgroups and genetic specificities.
    J Exp Med. 1966 Oct 1;124(4):715-32 PMID: 4162448
  7. Studies on papain produced subunits of human gamma-G-globulins. II. Structures of peptides related to the genetic Gm activity of gamma-G-globulin Fc-fragments.
    Immunochemistry. 1966 Jul;3(4):329-37 PMID: 4164840
  8. Gm(g)--a "new" gamma-globulin factor.
    Nature. 1966 Jul 16;211(5046):318-9 PMID: 4164920
  9. Genes and immunoglobulins.
    Vox Sang. 1966 Sep-Oct;11(5):521-45 PMID: 4165842
  10. Comparison of the C-terminal amino-acid sequence of two horse immunoglobulins IgG and IgG(T).
    Nature. 1966 Oct 8;212(5058):205-6 PMID: 4165950
  11. Skin-sensitizing activity related to gamma- polypeptide chain characteristics of human IgG.
    J Immunol. 1965 Dec;95(6):1041-7 PMID: 5850537
  12. Combinations of specific color reactions useful in the peptide mapping technique.
    Biochim Biophys Acta. 1965 Sep 13;107(2):386-8 PMID: 5880562
  13. Two types of gamma-globulin differing in carbohydrate content.
    Proc Soc Exp Biol Med. 1956 Oct;93(1):146-50 PMID: 13370604
  14. Agglutination of erythrocytes coated with incomplete anti-Rh by certain rheumatoid arthritic sera and some other sera; the existence of human serum groups.
    Acta Pathol Microbiol Scand. 1956;39(3):195-7 PMID: 13372249
  15. Hereditary serological human serum groups.
    Acta Pathol Microbiol Scand. 1956;39(6):390-8 PMID: 13381487
  16. The kinetics of hydrazinolysis of simple peptides in anhydrous hydrazine.
    Biochem J. 1958 Mar;68(3):475-82 PMID: 13522647
  17. The nature of the amino acid residues involved in the inactivation of ribonuclease by iodoacetate.
    J Biol Chem. 1959 Jul;234(7):1754-60 PMID: 13672958
  18. Reduction of gamma-globulins.
    Arch Biochem Biophys. 1962 Sep;Suppl 1:174-80 PMID: 13945475
  19. Localization of two genetic factors to different areas of gamma-globulin molecules.
    Science. 1962 Jun 15;136(3520):979-80 PMID: 14036038
  20. AMINO ACID COMPOSITIONS OF HUMAN AND RABBIT GAMMA-GLOBULINS AND OF THE FRAGMENTS PRODUCED BY REDUCTION.
    Biochem J. 1963 Aug;88:228-34 PMID: 14063860
  21. THE MOLECULAR WEIGHTS OF THE PEPTIDE CHAINS OF GAMMA-GLOBULIN.
    Biochem J. 1963 Aug;88:234-9 PMID: 14063861
  22. GAMMA GLOBULIN ANTIGENIC TYPES DEFINED BY HEAVY CHAIN DETERMINANTS.
    Science. 1964 Jul 10;145(3628):168-70 PMID: 14171556
  23. SUBCLASSES OF HUMAN GAMMA-2-GLOBULIN BASED ON DIFFERENCES IN THE HEAVY POLYPEPTIDE CHAINS.
    Science. 1964 Oct 16;146(3642):400-1 PMID: 14186462
  24. DITHIOTHREITOL, A NEW PROTECTIVE REAGENT FOR SH GROUPS.
    Biochemistry. 1964 Apr;3:480-2 PMID: 14192894
  25. A RELATIONSHIP BETWEEN THE H CHAIN GROUPS OF 7S GAMMA-GLOBULIN AND THE GM SYSTEM.
    Nature. 1964 Jul 25;203:413-4 PMID: 14197389
  26. H CHAIN SUBGROUPS OF MYELOMA PROTEINS AND NORMAL 7S GAMMA-GLOBULIN.
    J Exp Med. 1964 Aug 1;120:253-66 PMID: 14206440
  27. CLINICAL AND IMMUNOCHEMICAL STUDIES OF FOUR CASES OF HEAVY (H-GAMMA-2) CHAIN DISEASE.
    Am J Med. 1964 Sep;37:351-73 PMID: 14209282
  28. INHIBITION OF CHYMOTRYPSIN ACTIVITY IN CRYSTALLINE TRYPSIN PREPARATIONS.
    J Biol Chem. 1964 Jun;239:1799-803 PMID: 14213354
  29. STUDIES ON RIBONUCLEASE S. I. LIMITED CARBOXYPEPTIDASE DEGRADATION OF RIBONUCLEASE S-PROTEIN AND RIBONUCLEASE S-PEPTIDE: EFFECTS OF CHANGES IN PRIMARY STRUCTURE ON ENZYMIC ACTIVITY.
    J Biol Chem. 1964 Nov;239:3781-6 PMID: 14257607
  30. [DEMONSTRATION OF DIALYSABLE PEPTIDES ACCOMPANYING GAMMA-GLOBULINS IN THEIR PREPARATION].
    C R Hebd Seances Acad Sci. 1965 Jan 11;260:734-7 PMID: 14282917
  31. DISTRIBUTION OF ALLOTYPIC SPECIFICITIES ON THE PEPTIDE CHAINS OF HUMAN GAMMA-GLOBULIN.
    Immunology. 1965 Feb;8:206-12 PMID: 14295644
  32. The structure of human hemoglobin. III. The sequence of amino acids in the tryptic peptides of the alpha chain.
    J Biol Chem. 1962 Aug;237:2547-61 PMID: 14458212
  33. Studies on polynucleotides, lix. Further codon assignments from amino Acid incorporations directed by ribopolynucleotides containing repeating trinucleotide sequences.
    Proc Natl Acad Sci U S A. 1966 Dec;56(6):1899-906 PMID: 16591436
  34. The serum proteins in multiple myelomatosis.
    Biochem J. 1940 Sep;34(8-9):1248-57 PMID: 16747310
  35. The immunological activity of some of the chymotryptic peptides of sperm-whale myoglobin.
    Biochem J. 1965 Mar;94(3):545-56 PMID: 16749070
Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1051019
Published
1967-12-00
Pages
1019-28
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1198421
External Links
PubMed source DOI: 10.1042/bj1051019 PMC Full Text View journal details
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