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PMID: 16709632 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Functions of AMP-activated protein kinase in adipose tissue.

The Journal of physiology ·Vol. 574 ·No. Pt 1 ·2006-07-01 ·Pages 55-62

Daval M, Foufelle F, Ferré P

Abstract

AMP-activated protein kinase (AMPK) is involved in cellular energy homeostasis. Its functions have been extensively studied in muscles and liver. AMPK stimulates pathways which increase energy production (glucose transport, fatty acid oxidation) and switches off pathways which consume energy (lipogenesis, protein synthesis, gluconeogenesis). This has led to the concept that AMPK has an interesting pharmaceutical potential in situations of insulin resistance and it is indeed the target of existing drugs and hormones which improve insulin sensitivity. Adipose tissue is a key player in energy metabolism through the release of substrates and hormones involved in metabolism and insulin sensitivity. Activation of AMPK in adipose tissue can be achieved through situations such as fasting and exercise. Leptin and adiponectin as well as hypoglycaemic drugs are activators of adipose tissue AMPK. This activation probably involves changes in the AMP/ATP ratio and the upstream kinase LKB1. When activated, AMPK limits fatty acid efflux from adipocytes and favours local fatty acid oxidation. Since fatty acids have a key role in insulin resistance, especially in muscles, activating AMPK in adipose tissue might be found to be beneficial in insulin-resistant states, particularly as AMPK activation also reduces cytokine secretion in adipocytes.

MeSH Terms
AMP-Activated Protein Kinases Adipose Tissue/enzymology Animals Fatty Acids/metabolism Glucose/metabolism Humans Lipid Metabolism/physiology Multienzyme Complexes/metabolism Muscle, Skeletal/physiology Protein Serine-Threonine Kinases/metabolism
Chemicals
Fatty Acids Multienzyme Complexes Protein Serine-Threonine Kinases AMP-Activated Protein Kinases Glucose
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Daval Marie
INSERM Unit 671, Paris 75006, France.
Foufelle Fabienne
Ferré Pascal
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Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1113/jphysiol.2006.111484
Published
2006-07-01
Epub
2006-00-18
Pages
55-62
Language
English
Region
England
NLM ID
0266262
PMCID
PMC1817807
Subset
IM
External Links
PubMed source DOI: 10.1113/jphysiol.2006.111484 PMC Full Text View journal details
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