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题目:: No effect of prolonged corticosterone over-exposure on NCAM, SGK1, and RGS4 mRNA expression in rat hippocampus.
作者:: van Gemert(Neeltje G),van Riel(Els),Meijer(Onno C),Fehr(Susanne),Schachner(Melitta),Joëls(Marian)
状态:: 发布时间2006-07-03 , 更新时间 2013-11-21
期刊:: Brain Res
摘要:: Prolonged over-exposure of rats to corticosterone attenuates 5-HT(1A)-receptor-mediated responses in hippocampal CA1 cells through an unknown mechanism, not involving downregulation of 5-HT(1A) receptor expression. We here tested if corticosterone changes 5-HT(1A) receptor function indirectly, by altering hippocampal mRNA expression of NCAM, SGK1, or RGS4, which all modulate 5-HT(1A) receptor function. We found that the expression of none of these candidates was affected by corticosterone treatment.
语言:: eng
DOI:: 10.1016/j.brainres.2006.03.083

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