Imidazolinones: potent inhibitors of acetohydroxyacid synthase.
The imidazolinones, a new chemical class of herbicides, were shown to be uncompetitive inhibitors of acetohydroxyacid synthase from corn. This is the first common enzyme in the biosynthetic pathway for valine, leucine, and isoleucine. The K(i) for the imidazolinones tested ranged from 2 to 12 micromolar. These results may explain the mechanism of action of these new herbicides.
5 references, click to expand
-
THE INCORPORATION OF C-ADENINE AND C-PHENYLALANINE BY DEVELOPING ROOT-TIP CELLS.Proc Natl Acad Sci U S A. 1957 Dec 15;43(12):1038-46 PMID: 16590133
-
Cooperative feedback control of barley acetohydroxyacid synthetase by leucine, isoleucine, and valine.Arch Biochem Biophys. 1971 Oct;146(2):542-50 PMID: 5114918
-
The Site of the Inhibition of the Shikimate Pathway by Glyphosate: II. INTERFERENCE OF GLYPHOSATE WITH CHORISMATE FORMATION IN VIVO AND IN VITRO.Plant Physiol. 1980 Nov;66(5):830-4 PMID: 16661535
-
Acetolactate synthase is the site of action of two sulfonylurea herbicides in higher plants.Science. 1984 Jun 29;224(4656):1443-5 PMID: 17793381
-
The effect of leucine on the biosynthesis of leucine in maize root tips.Plant Physiol. 1965 Jan;40(1):149-55 PMID: 5831097
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: product@genelibs.com
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
