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PMID: 1665101 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Coexpression of platelet-derived growth factor (PDGF) B chain and PDGF B-type receptor in human gliomas.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery ·Vol. 7 ·No. 8 ·1991-12-00 ·Pages 432-6

Mauro A, Bulfone A, Turco E, Schiffer D

Abstract

In this study we analyzed the expression of mRNA for PDGF-B and PDGF B-type receptor (PDGFrecB) in 42 biopsy specimens from human astrocytic gliomas and other brain tumors. All gliomas expressed PDGF-B mRNA at higher levels than found in peritumoral and normal nervous tissues. Levels of PDGF-B transcripts correlated strongly with those of mRNA for glial fibrillary acidic protein. Thus, the production of PDGF-B mRNA may be attributed mainly to tumoral glial cells. PDGFrecB transcripts were found in 24 out of 29 gliomas, in agreement with the hypothesis of an autocrine growth stimulation in these tumors. Moreover, mean levels of PDGFrecB expression were higher in glioblastomas than in astrocytomas and over 30-fold higher in meningiomas than in gliomas. This suggests that in gliomas PDGFrecB can be expressed also by vascular elements, in agreement with the hypothesized existence of a paracrine mechanism that may be responsible for the endothelial hyperplasias.

MeSH Terms
Astrocytoma/genetics,pathology Biopsy Brain Neoplasms/genetics,pathology Cerebellar Neoplasms/genetics,pathology Child Gene Expression Regulation, Neoplastic/physiology Glial Fibrillary Acidic Protein/genetics Glioma/genetics,pathology Humans Medulloblastoma/genetics,pathology Platelet-Derived Growth Factor/genetics Proto-Oncogene Proteins/genetics Proto-Oncogene Proteins c-sis RNA, Messenger/genetics Receptors, Cell Surface/genetics Receptors, Platelet-Derived Growth Factor Transcription, Genetic/genetics
Chemicals
Glial Fibrillary Acidic Protein Platelet-Derived Growth Factor Proto-Oncogene Proteins Proto-Oncogene Proteins c-sis RNA, Messenger Receptors, Cell Surface Receptors, Platelet-Derived Growth Factor
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Mauro A
Second Neurological Clinic, University of Turin, Italy.
Bulfone A
Turco E
Schiffer D
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24 references, click to expand
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Article Info
Journal
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
Abbr.
Childs Nerv Syst
ISSN
0256-7040
DOI
10.1007/BF00263184
Published
1991-12-00
Pages
432-6
Language
English
Region
Germany
NLM ID
8503227
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00263184 View journal details
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