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PMID: 16647857 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Ubiquitin and SUMO systems in the regulation of mitotic checkpoints.

Trends in biochemical sciences ·Vol. 31 ·No. 6 ·2006-06-00 ·Pages 324-32

Gutierrez GJ, Ronai Z

Abstract

Proteolysis mediated by the ubiquitin-proteasome system is a crucial regulatory mechanism in signal transduction cascades of temporal cellular processes such as cell division. Two principal subtypes of modular ubiquitin ligase, the anaphase-promoting complex or cyclosome (APC/C) and the Skp1/Cullin-1/F-box protein complex, have emerged as essential regulators of key events in the cell cycle. The importance of these ligases is best illustrated by their roles in the checkpoint and repair pathways or in response to multiple stresses, where they affect activation of the M-phase-promoting factor or proper formation and/or maintenance of the mitotic spindle. Recent studies have considerably improved our understanding of the function of the concerted action of the phosphorylation and ubiquitin or SUMO systems in the regulation of the stability and activity of key components of the mitotic checkpoint.

MeSH Terms
Anaphase/physiology Animals Cell Division/physiology Humans Phosphorylation Proteasome Endopeptidase Complex/metabolism Protein Processing, Post-Translational/physiology SUMO-1 Protein/metabolism Signal Transduction/physiology Ubiquitin/metabolism
Chemicals
SUMO-1 Protein Ubiquitin Proteasome Endopeptidase Complex
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Gutierrez Gustavo J
Signal Transduction Program, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. gustavo@burnham.org
Ronai Ze'ev
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Article Info
Journal
Trends in biochemical sciences
Abbr.
Trends Biochem Sci
ISSN
0968-0004
DOI
10.1016/j.tibs.2006.04.001
Email
gustavo@burnham.org
Published
2006-06-00
Epub
2006-00-02
Pages
324-32
Language
English
Region
England
NLM ID
7610674
PMCID
PMC3061571
Subset
IM
Grants
NCI NIH HHS · R01 CA078419 · United States
NCI NIH HHS · R01 CA078419-06 · United States
NCI NIH HHS · CA078419 · United States
External Links
PubMed source DOI: 10.1016/j.tibs.2006.04.001 PMC Full Text View journal details
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