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题目:: Cooperative IFN-gamma production of mouse liver B cells and natural killer cells stimulated with lipopolysaccharide.
作者:: Matsumoto(Atsushi),Kinoshita(Manabu),Ono(Satoshi),Tsujimoto(Hironori),Majima(Takashi),Habu(Yoshiko),Shinomiya(Nariyoshi),Seki(Shuhji)
状态:: 发布时间2006-07-14 , 更新时间 2008-11-21
期刊:: J Hepatol
摘要:: Although mouse liver contains a large population of B cells, little is known about how hepatic B cells respond to bacterial lipopolysaccharide (LPS).,The cytokine and IgM productions of hepatic B cells were compared with those of splenic B cells. The effect of LPS-treated hepatic B cells on IFN-gamma production from co-cultured NK1.1+ cells was also examined by irradiation and transwell experiments.,Hepatic B cells stimulated with LPS produced substantial amounts of IFN-gamma and IL-12 but a small amount of IgM, while splenic B cells did not produce any of these cytokines but produced a large amount of IgM. The hepatic B cells expressed surface markers similar to those on spleen B cells but expressed more C-X-C chemokine receptor 3 than spleen B cells. Notably, depletion of B220+ cells from liver MNCs (but not from spleen MNCs) greatly decreased LPS-induced IFN-gamma production. Furthermore, LPS-treated hepatic B cells stimulated liver NK1.1+ cells to produce a remarkable amount of IFN-gamma, not only through their soluble factors but also through direct cell-cell contact.,Liver B cells may play an important role in the defense against gram-negative bacterial infections by inducing IFN-gamma production from liver NK cells.
语言:: eng
DOI:: 10.1016/j.jhep.2006.02.012

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