Immunodeficiency in the chicken. I. Disparity in suppression of antibody responses to various antigens following surgical bursectomy.
The extent of suppression of antibody response by bursectomy (Bx) was examined as a measure of the seeding sequence of different clones from the bursa to peripheral lymphoid tissues. Chickens were bursectomized surgically 1, 4 or 7 days after hatching and immunized later with four antigens: sheep red blood cells (SRBC); Bordetella pertussis (Bp); human serum albumin (HSA); influenza virus (IV). The kinetics of the antibody responses were delayed in bursectomized birds when compared with the control groups. The following order in the degree of immunosuppression was established: Bp greater than HSA greater than SRBC greater than IV. This is discussed in relation to the 'sequential maturation' theory of ontogenesis of immunocyte differentiation. The data also stress the limitation of non-specific markers for assessing partial immunodeficiency states.
16 references, click to expand
-
Normal development of the thymus-dependent limb of humoral immune responses in mice.Eur J Immunol. 1973 Aug;3(8):506-11 PMID: 4127818
-
The dose of antigen required for the suppression of the IgM and IgG antibody response in chickens. I. The kinetics and characterization of serum antibodies.Folia Biol (Praha). 1966;12(3):157-67 PMID: 5945807
-
Immunoglobulin synthesis and lymphocyte transformation by anti-immunoglobulin sera in bursectomized chickens.Immunology. 1969 Sep;17(3):325-31 PMID: 4187455
-
The role of lymphocytes in antibody formation. II. The influence of lymphocyte migration on the initiation of antibody formation in the isolated, perfused spleen.Proc R Soc Lond B Biol Sci. 1967 Sep 12;168(1012):244-62 PMID: 4383553
-
Enumeration and analysis of antibody-forming cell precursors in the neonatal mouse.J Immunol. 1973 Sep;111(3):829-35 PMID: 4542609
-
Sequential recruitment of antibody class-committed B lymphocytes during ontogeny.Eur J Immunol. 1973 Dec;3(12):789-93 PMID: 4544461
-
A quantitative assay for the progenitors of bone marrow-associated lymphocytes.J Exp Med. 1972 Jun 1;135(6):1363-74 PMID: 4554453
-
Functional development of the interacting cells in the immune response. I. Development of T cell and B cell function.J Immunol. 1972 May;108(5):1379-86 PMID: 4555116
-
The generation of antigen sensitive cells in the newborn mouse.J Immunol. 1972 Dec;109(6):1345-51 PMID: 4563879
-
Characterization of splenic lymphoid cells in fetal and newborn mice.J Exp Med. 1973 Sep 1;138(3):557-73 PMID: 4580464
-
Ontogeny of haemolytic plaque-forming cells in newborn rabbit's spleen in response to different erythrocyte antigens.Immunology. 1974 May;26(5):1061-7 PMID: 4604855
-
Immunochemical quantitation of antigens by single radial immunodiffusion.Immunochemistry. 1965 Sep;2(3):235-54 PMID: 4956917
-
Development and distribution of immunoglobulin-containing cells in the chicken. An immunofluorescent analysis using purified antibodies to mu, gamma and light chains.J Immunol. 1971 Feb;106(2):371-82 PMID: 5101790
-
Proliferative and differentiative manifestations of cellular immune potential.Prog Allergy. 1967;10:1-36 PMID: 5333336
-
Role of macrophages in immunological maturation.J Exp Med. 1968 Sep 1;128(3):459-67 PMID: 5666960
-
Ontogeny of the murine immune system: development of antigen recognition and immune responsiveness.Eur J Immunol. 1973 Apr;3(4):224-8 PMID: 4146083
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: product@genelibs.com
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
