Use and selectivity of herbimycin A as inhibitor of protein-tyrosine kinases.

src

Animals Antibiotics, Antineoplastic/pharmacology Avian Sarcoma Viruses/genetics Benzoquinones Cell Division/drug effects Cell Line Cell Transformation, Neoplastic/drug effects Genes, src/drug effects Humans Lactams, Macrocyclic Oncogene Protein pp60(v-src)/antagonists & inhibitors Protein-Tyrosine Kinases/antagonists & inhibitors Quinones/isolation & purification,pharmacology Rats Rifabutin/analogs & derivatives Streptomyces

Antibiotics, Antineoplastic Benzoquinones Lactams, Macrocyclic Quinones Rifabutin herbimycin Protein-Tyrosine Kinases Oncogene Protein pp60(v-src)