Connecting cancer to the asymmetric division of stem cells.
作者:
Wodarz(Andreas),Gonzalez(Cayetano)
状态:
发布时间2006-03-27
, 更新时间 2008-10-16
期刊:
Cell
摘要:
Two studies, one in this issue of Cell and the other in Developmental Cell show that the cell-fate determinant Brain Tumor (Brat) suppresses self-renewal in one of the daughter cells that arise from the asymmetric division of a neural stem cell. This work suggests a mechanism by which loss of polarity in stem cells may lead to tumorigenesis.