Morphological changes induced by dextran sulfate 500 in mononuclear phagocytes of listeria-infected mice.

Infection and immunity ·Vol. 10 ·No. 5 ·1974-11-00 ·Pages 1110-9

Hahn H, Bierther M

Abstract

Morphological changes involving mononuclear phagocytes in Listeria-infected mice after treatment with dextran sulfate 500 were investigated. Mononuclear phagocytes in livers and spleens, both circulating monocytes and fixed macrophages, showed uptake of electron-dense material. Mononuclear phagocyte changes were most pronounced within granulomatous lesions, where many phagocytes showed large membrane-bound inclusions and extensive cellular damage. It is concluded that dextran sulfate 500 selectively damages mononuclear phagocytes and that, in listerial infection, dextran sulfate 500 renders mononuclear phagocytes unable to express cellular resistance.

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Hahn H

Institut für Medizinische Mikrobiologie, Johannes Gutenberg-University, D-65 Mainz, Germany.

Bierther M

References (13)

13 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.10.5.1110-1119.1974

Published

1974-11-00

Pages

1110-9

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC423070

External Links

PubMed source DOI: 10.1128/iai.10.5.1110-1119.1974 PMC Full Text View journal details

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Morphological changes induced by dextran sulfate 500 in mononuclear phagocytes of listeria-infected mice.

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