Sensitivity of Types 1 and 2 Herpes Simplex Virus to 5-Iodo-2'-Deoxyuridine and 9-beta-d-Arabinofuranosyladenine.

Infection and immunity ·Vol. 2 ·No. 6 ·1970-12-00 ·Pages 815-20

Person DA, Sheridan PJ, Herrmann EC

Abstract

The sensitivities of 21 strains of herpes simplex virus (HSV), 13 type 1 strains and 8 type 2 strains, to 5-iodo-2'-deoxyuridine (IUdR) and 9-beta-d-arabinofuranosyladenine (ara-A) were evaluated by the plaque-suppression test in chick embryo fibroblast (CEF), WI-38, and HeLa cell cultures. In CEF, type 1 strains were considerably more sensitive to the inhibitors than were the type 2 strains. In WI-38, the type 1 strains were more sensitive than the type 2 strains to IUdR; however, the two serotypes were equally sensitive to ara-A. In HeLa cells, the differences in sensitivity to IUdR between the two serotypes were less. Eight HeLa-adapted strains (four type 1 and four type 2) evaluated in HeLa cell cultures were equally sensitive to IUdR; the type 2 strains were slightly more sensitive than type 1 strains to ara-A. These results demonstrate the wide variation in sensitivity of HSV types 1 and 2 to antiviral agents which results from differences in the cell culture system and passage history of the strains.

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Person D A

Mayo Graduate School of Medicine (University of Minnesota), and Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55901.

Sheridan P J

Herrmann E C

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.2.6.815-820.1970

Published

1970-12-00

Pages

815-20

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC416096

External Links

PubMed source DOI: 10.1128/iai.2.6.815-820.1970 PMC Full Text View journal details

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Sensitivity of Types 1 and 2 Herpes Simplex Virus to 5-Iodo-2'-Deoxyuridine and 9-beta-d-Arabinofuranosyladenine.

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