Immunity in Experimental Salmonellosis I. Protection Induced by Rough Mutants of Salmonella typhimurium.

Infection and immunity ·Vol. 2 ·No. 3 ·1970-09-00 ·Pages 309-15

Germanier R

Abstract

Different rough mutants of Salmonella typhimurium were tested to determine their virulence and immunizing capacity when used as live vaccines for mice. All uridine diphosphate-galactose-4-epimeraseless mutants tested were much more potent immunizing agents than any other mutants. This capacity was not correlated with virulence or complexity of cell wall polysaccharide. For good protection, persistence of the rough strains in vivo was essential, but the protection lasted longer than the period during which bacteria were demonstrable in the liver and spleen of the mice. The outstanding immunizing capacity of the "epimeraseless" mutants is not dependent on the persistence of viable bacteria in the mouse.

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Germanier R

Swiss Serum and Vaccine Institute, Berne, Switzerland.

References (15)

15 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.2.3.309-315.1970

Published

1970-09-00

Pages

309-15

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC416007

External Links

PubMed source DOI: 10.1128/iai.2.3.309-315.1970 PMC Full Text View journal details

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Immunity in Experimental Salmonellosis I. Protection Induced by Rough Mutants of Salmonella typhimurium.

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