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PMID: 16557684 Published · ppublish English Journal Article

Resistance factor-mediated spectinomycin resistance.

Infection and immunity ·Vol. 1 ·No. 1 ·1970-01-00 ·Pages 120-7

Smith DH, Janjigian JA, Prescott N, Anderson PW

Abstract

Of 100 natural isolates of drug-resistant enteric bacteria, 51 were resistant to spectinomycin (Spc) and 46 contained transferable R factors mediating Spc resistance. All Spc(R) R factors mediated streptomycin and bluensomycin resistance and were fi(+) type. Extracts of R-Spc(R) strains adenylated Spc, dihydrospectinomycin, actinamine, streptomycin, and bluensomycin in vitro in the presence of adenosine triphosphate and Mg(++). Results of genetic and biochemical studies support the hypothesis that these reactions are mediated by a single enzyme.

Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Smith D H
Department of Pediatrics, Harvard Medical School and Children's Hospital Medical Center, Boston, Massachusetts 02115.
Janjigian J A
Prescott N
Anderson P W
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.1.1.120-127.1970
Published
1970-01-00
Pages
120-7
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC415863
External Links
PubMed source DOI: 10.1128/iai.1.1.120-127.1970 PMC Full Text View journal details
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