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PMID: 16554912 Published · ppublish English Journal Article

The intratumoral microvessel density and expression of bFGF and nm23-H1 in colorectal cancer.

Pathology oncology research : POR ·Vol. 12 ·No. 1 ·2006-00-00 ·Pages 21-7

Elagoz S, Egilmez R, Koyuncu A, Muslehiddinoglu A, Arici S

Abstract

It has previously been reported that intratumoral microvessel density (IMD), and the expression of bFGF and nm23-H1 are useful prognostic markers in colorectal cancer (CRC). In this study, a total of 100 CRCs were evaluated histopathologically, and IMD, bFGF and nm23-H1 expression were assessed by immunohistochemistry. IMD of patients increased with grade and stage, and this increase was statistically significant (p<0.05). A significantly higher incidence of high bFGF expression scores was also associated with increasing grade and stage (p<0.05). However, there was no significant difference between the grades in nm23-H1 expression (p=0.234). nm23-H1 expression occurred with lower incidence in stages C1, C2 and D than in stages B1 and B2 (p<0.05). Thus, a negative correlation was found between nm23-H1 expression and stage or lymph node metastasis (LNM) (p<0.05). IMD and bFGF expression were positively correlated with grade, stage, LNM, and lymphovascular invasion. Although positive correlation was found between IMD and bFGF, nm23-H1 expression negatively correlated with both of them. As a result, in clinical practice, increased IMD and bFGF expression and decreased nm23-H1 expression may provide valuable information in characterizing the malignant phenotype.

MeSH Terms
Biomarkers, Tumor/analysis Colorectal Neoplasms/blood supply,pathology Female Fibroblast Growth Factors/biosynthesis Humans Immunohistochemistry Lymphatic Metastasis/pathology Male Middle Aged NM23 Nucleoside Diphosphate Kinases Neoplasm Staging Neovascularization, Pathologic Nucleoside-Diphosphate Kinase/biosynthesis Prognosis
Chemicals
Biomarkers, Tumor NM23 Nucleoside Diphosphate Kinases Fibroblast Growth Factors NME1 protein, human Nucleoside-Diphosphate Kinase
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Elagoz Sahande
Department of Pathology, Cumhuriyet University School of Medicine, Sivas, 58140, Turkey. selagoz@cumhuriyet.edu.tr
Egilmez Reyhan
Koyuncu Ayhan
Muslehiddinoglu Ahmet
Arici Sema
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Article Info
Journal
Pathology oncology research : POR
Abbr.
Pathol Oncol Res
ISSN
1219-4956
DOI
10.1007/BF02893427
Email
selagoz@cumhuriyet.edu.tr
Published
2006-00-00
Epub
2006-00-23
Pages
21-7
Language
English
Region
Switzerland
NLM ID
9706087
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02893427 View journal details
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