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题目:: BRCA1-positive breast cancers in young women from Poland.
作者:: Lubiński(J),Górski(B),Huzarski(T),Byrski(T),Gronwald(J),Serrano-Fernández(P),Domagała(W),Chosia(M),Uciński(M),Grzybowska(E),Lange(D),Maka(B),Mackiewicz(A),Karczewska(A),Breborowicz(J),Lamperska(K),Stawicka(M),Gozdecka-Grodecka(S),Bebenek(M),Sorokin(D),Wojnar(A),Haus(O),Sir(J),Mierzwa(T),Niepsuj(S),Gugała(K),Góźdź(S),Sygut(J),Kozak-Klonowska(B),Musiatowicz(B),Posmyk(M),Kordek(R),Morawiec(M),Zambrano(O),Waśko(B),Fudali(L),Skret(J),Surdyka(D),Urbański(K),Mituś(J),Ryś(J),Szwiec(M),Rozmiarek(A),Dziuba(I),Wandzel(P),Wiśniowski(R),Szczylik(C),Kozak(A),Kozłowski(W),Narod(S A)
状态:: 发布时间2006-08-09 , 更新时间 2006-08-09
期刊:: Breast Cancer Res Treat
摘要:: We identified 4316 unselected incident cases of early-onset breast cancers (<51 ears of age at diagnosis) in 18 Polish hospitals between 1996 and 2003. We were able to obtain a blood sample for DNA analysis from 3472 of these (80.4%). All cases were tested for the presence of three founder mutations in BRCA1. The proportion of cases with a BRCA1 mutation was 5.7%. The hereditary proportions were higher than this for women with breast cancer diagnosed before age 40 (9%), for women with cancer of medullary or atypical medullary histology (28%), for those with bilateral cancer (29%) or with a family history of breast or ovarian cancer (13%). It is reasonable to offer genetic testing to women with early-onset breast cancer in Poland.
语言:: eng
DOI:: 10.1007/s10549-006-9182-3

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