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PMID: 1653517 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Association of Epstein-Barr virus with undifferentiated gastric carcinomas with intense lymphoid infiltration. Lymphoepithelioma-like carcinoma.

The American journal of pathology ·Vol. 139 ·No. 3 ·1991-09-00 ·Pages 469-74

Shibata D, Tokunaga M, Uemura Y, Sato E, Tanaka S, Weiss LM

Abstract

Some undifferentiated gastric carcinomas with intense lymphoid infiltration have a striking resemblance to nasopharyngeal lymphoepithelioma. The authors identified eight such cases (seven patients from Japan and one from the United States) of undifferentiated gastric carcinoma (lymphoepithelioma-like carcinoma [LELC]) and examined them for Epstein-Barr (EBV) viral sequences using polymerase chain reaction (PCR) and in situ hybridization (ISH) techniques. EBV was detected in seven of the eight cases by PCR, including a lymph-node metastasis. ISH that was performed in six of these cases showed EBV genomes to be uniformly present in the carcinoma cells and not present in the reactive lymphoid infiltrate or normal gastric mucosa. PCR of a polymorphic EBV locus (lymphocyte-determined membrane antigen) showed that a single genotype was present in each gastric LELC, consistent with a clonal process. These findings suggest that some undifferentiated gastric carcinomas are EBV-related and that focal EBV infection occurs before transformation.

MeSH Terms
Antigens, Surface/genetics Carcinoma, Squamous Cell/microbiology,pathology DNA, Viral/analysis Genes, Viral/genetics Herpesvirus 4, Human/genetics,isolation & purification Humans Immunohistochemistry Lymphoid Tissue/pathology Nucleic Acid Hybridization Polymerase Chain Reaction Stomach Neoplasms/microbiology,pathology
Chemicals
Antigens, Surface DNA, Viral
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Shibata D
Department of Pathology, Los Angeles County-University of Southern California Medical Center 90033.
Tokunaga M
Uemura Y
Sato E
Tanaka S
Weiss L M
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1991-09-00
Pages
469-74
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1886210
Subset
IM
Grants
NCI NIH HHS · CA50850 · United States
External Links
PubMed source PMC Full Text View journal details
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