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PMID: 16533859 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Effect of hydrophobic mismatch on phase behavior of lipid membranes.

Biophysical journal ·Vol. 90 ·No. 11 ·2006-06-01 ·Pages 4104-18

Wallace EJ, Hooper NM, Olmsted PD

Abstract

We investigate the competing effects of hydrophobic mismatch and chain stretching on the morphology and evolution of domains in lipid membranes via Monte Carlo techniques. We model the membrane as a binary mixture of particles that differ in their preferred lengths, with the shorter particles mimicking unsaturated nonraft lipids and the longer particles mimicking saturated raft lipids. We find that phase separation can be induced upon increasing either the ratio J/kappa of the hydrophobic surface tension J to the compressibility modulus kappa. J/kappa determines the decay length for thickness changes. When this decay length is larger than the system size the membrane remains mixed. Furthermore, increasing the thickness relaxation time can induce transient phase separation.

MeSH Terms
Computer Simulation Hydrophobic and Hydrophilic Interactions Lipid Bilayers/chemistry Membrane Fluidity Models, Chemical Monte Carlo Method Phase Transition Thermodynamics
Chemicals
Lipid Bilayers
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Wallace Elizabeth J
School of Biochemistry & Microbiology, Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.
Hooper Nigel M
Olmsted Peter D
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Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
0006-3495
DOI
10.1529/biophysj.105.062778
Published
2006-06-01
Epub
2006-00-13
Pages
4104-18
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC1459530
Subset
IM
Grants
Wellcome Trust · United Kingdom
External Links
PubMed source DOI: 10.1529/biophysj.105.062778 PMC Full Text View journal details
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