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题目:: Asymmetric stem cell division and function of the niche in the Drosophila male germ line.
作者:: Yamashita(Yukiko M),Fuller(Margaret T)
状态:: 发布时间2006-03-15 , 更新时间 2007-11-14
期刊:: Int J Hematol
摘要:: The balance between stem cell and differentiating cell populations is critical for the long-term maintenance of tissue renewal for cell types derived from adult stem cell lineages such as blood, skin, intestinal epithelium, and sperm. To keep this balance, stem cells have the potential to divide asymmetrically, producing one daughter cell that maintains stem cell identity and one daughter cell that initiates differentiation. In many adult stem cell systems, the maintenance, proliferation, and number of stem cells appear to be controlled by the microenvironment, or niche. The Drosophila male and female germ line provide excellent model systems in which to study asymmetric stem cell divisions within the stem cell niche. In addition to signals from the niche that specify stem cell self-renewal, the stem cells themselves have elaborate cellular mechanisms to ensure the asymmetric outcome of cell division.
语言:: eng
DOI:: 10.1532/IJH97.05097

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