Bruno: a double turn-off for Oskar.

Developmental cell ·Vol. 10 ·No. 3 ·2006-03-00 ·Pages 280-1

Tekotte H, Davis I

Abstract

In Drosophila, the posterior localization of oskar mRNA and its translational regulation are essential for axis specification and germline formation. Recently in Cell, demonstrated that Bruno inhibits cap-dependent translation of oskar mRNA and uncovered a novel Bruno-dependent assembly of oskar mRNA into multimeric RNP particles, which are inaccessible to the translational machinery. This work provides a novel link between mRNA localization, particle formation, and translational regulation.

MeSH Terms

Animals Drosophila Proteins/genetics,metabolism Drosophila melanogaster/physiology Gene Silencing Protein Biosynthesis RNA, Messenger/metabolism RNA-Binding Proteins/genetics,metabolism

Chemicals

Drosophila Proteins RNA, Messenger RNA-Binding Proteins bru1 protein, Drosophila osk protein, Drosophila

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Tekotte Hille

Wellcome Trust Centre for Cell Biology, Michael Swann Building, School of Biological Sciences, The University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, United Kingdom.

Davis Ilan

Article Info

Journal

Developmental cell

Abbr.

Dev Cell

ISSN

1534-5807

DOI

10.1016/j.devcel.2006.02.001

Published

2006-03-00

Pages

280-1

Language

English

Region

United States

NLM ID

101120028

Subset

Corrections

CommentOn

PMID: 16469699

External Links

PubMed source DOI: 10.1016/j.devcel.2006.02.001 View journal details

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