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PMID: 1649507 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Identification and DNA sequence of the large subunit of the capping enzyme from Shope fibroma virus.

Virology ·Vol. 183 ·No. 2 ·1991-08-00 ·Pages 773-7

Upton C, Stuart D, McFadden G

Abstract

A 3.6-kb region of the Shope fibroma virus (SFV) BamHI D fragment located in the central region of the viral genome was sequenced. Three open reading frames (ORFs) were identified, D3R, D4L, and D5R. Each of these ORFs have a counterpart organized identically within the HindIII fragment D of the vaccinia virus genome (D1R, D2L, and D3R). Homology scores and assays of viral cores indicate that SFV D3R encodes the large subunit of the SFV mRNA capping enzyme.

MeSH Terms
Amino Acid Sequence Base Sequence DNA, Viral Fibroma Virus, Rabbit/enzymology,genetics Genes, Viral Methyltransferases/genetics Molecular Sequence Data Multienzyme Complexes/genetics Nucleotidyltransferases/genetics Open Reading Frames Phosphoric Monoester Hydrolases/genetics RNA Caps Restriction Mapping Sequence Alignment Sequence Homology, Nucleic Acid Viral Proteins
Chemicals
DNA, Viral Multienzyme Complexes RNA Caps Viral Proteins Methyltransferases Nucleotidyltransferases Phosphoric Monoester Hydrolases capping enzyme, vaccinia virus
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Upton C
Department of Biochemistry, University of Alberta, Edmonton, Canada.
Stuart D
McFadden G
Article Info
Journal
Virology
Abbr.
Virology
ISSN
0042-6822
Published
1991-08-00
Pages
773-7
Language
English
Region
United States
NLM ID
0110674
Subset
IM
Databases
GENBANK
M55473, M55474, M55475, M55476, M55477, M55478, M63902, M64315, M64316, S42893
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