| GeneLibs

题目:: Alterations of the CCND1 and HER-2/neu (ERBB2) proteins in esophageal and gastric cancers.
作者:: Bizari(Lucimari),Borim(Aldenis Albanese),Leite(Kátia Ramos Moreira),Gonçalves(Fernanda de Toledo),Cury(Patrícia Maluf),Tajara(Eloiza Helena),Silva(Ana Elizabete)
状态:: 发布时间2006-02-21 , 更新时间 2014-11-20
期刊:: Cancer Genet Cytogenet
摘要:: We evaluated the relationship of amplification and polysomy of both the CCND1 and the ERBB2 (alias HER-2/NEU) genes to the overexpression of their proteins in esophageal and gastric cancers and also their association with clinicopathological features. CCND1 gene amplification (45%) was more prevalent than polysomy (25%) in esophageal carcinoma, but the pattern observed was similar in gastric adenocarcinoma (10% amplification, 15% polysomy). For ERBB2, polysomy was a more frequent mechanism than amplification in both esophageal (32.5 vs. 7.5%) and gastric (15 vs. 5%) cancers. Overexpression of cyclin D1 protein was identified in 37.5% of the specimens of esophageal tumors and 35% of gastric tumors, and overexpression of Her-2/neu protein in 12.5 and 7.5%, respectively. The kappa-statistics revealed a fair agreement in both types of tumors only in overexpression and amplification of the CCND1 gene; the ERBB2 gene showed a fair agreement in amplification and polysomy and the level of protein expression in gastric adenocarcinoma. Thus, polysomy 17 could contribute to a high Her-2/neu protein level, at least in gastric cancer. Our data indicated an association with alcohol consumption and the CCND1 gene or protein levels, in both esophageal and gastric cancers.
语言:: eng
DOI:: 10.1016/j.cancergencyto.2005.08.031

文献库文献相关信息

DataTable pData

联系方式

微信公众号

文献库 文献相关信息

DataTable pData

联系方式

微信公众号

文献库文献相关信息