The role of lipopolysaccharide-binding protein in modulating the innate immune response.

Microbes and infection ·Vol. 8 ·No. 3 ·2006-03-00 ·Pages 946-52

Zweigner J, Schumann RR, Weber JR

Abstract

Lipopolysaccharide-binding protein (LBP) has a well-established role in Gram-negative infection. New data suggest a more expanded role for LBP as a general recognition molecule. Several bacterial surface components from Gram-positive pathogens are also recognized by this molecule. LBP may also serve as a clinical marker in severe infections and may carry therapeutic potential.

MeSH Terms

Acute-Phase Proteins/immunology,metabolism Bacterial Infections/immunology Carrier Proteins/immunology,metabolism Humans Immunity, Innate Lipopolysaccharides/immunology,metabolism Membrane Glycoproteins/immunology,metabolism Mycoses/immunology

Chemicals

Acute-Phase Proteins Carrier Proteins Lipopolysaccharides Membrane Glycoproteins lipopolysaccharide-binding protein

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Zweigner Janine

Institut für Mikrobiologie und Hygiene, Charité-Universitaetsmedizin Berlin, Schumannstrasse 21/22, D-10117 Berlin, Germany.

Schumann Ralf R

Weber Joerg R

Article Info

Journal

Microbes and infection

Abbr.

Microbes Infect

ISSN

1286-4579

DOI

10.1016/j.micinf.2005.10.006

Published

2006-03-00

Epub

2006-00-13

Pages

946-52

Language

English

Region

France

NLM ID

100883508

Subset

External Links

PubMed source DOI: 10.1016/j.micinf.2005.10.006 View journal details

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The role of lipopolysaccharide-binding protein in modulating the innate immune response.

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