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题目:: B lymphocytes in humans express ZAP-70 when activated in vivo.
作者:: Cutrona(Giovanna),Colombo(Monica),Matis(Serena),Reverberi(Daniele),Dono(Mariella),Tarantino(Vincenzo),Chiorazzi(Nicholas),Ferrarini(Manlio)
状态:: 发布时间2006-03-08 , 更新时间 2009-11-19
期刊:: Eur J Immunol
摘要:: ZAP-70 is a protein tyrosine kinase initially found in T and NK cells. Recently, this important signaling element was detected in leukemic B cells from a subgroup of patients with B cell chronic lymphocytic leukemia (B-CLL). In this study, ZAP-70 was detected in normal B cells from human tonsils, but not from peripheral blood. The cDNA sequence of B cell ZAP-70 was the same as that in T cells. Germinal center B cells and plasma cells had a substantial proportion of ZAP-70+ cells, while memory and follicular mantle B cells, which contain low numbers of activated B cells, expressed relatively little ZAP-70. A cell fraction of IgD+, CD38+ B cells, which are comprised of many in vivo activated B cells, exhibited the highest levels of ZAP-70. Density gradient fractionation of tonsil B cells confirmed that ZAP-70 was not expressed by resting B cells, but was expressed by buoyant, in vivo activated B cells. In these B cells, the expression of ZAP-70 correlated with that of CD38 and not with that of CD5, a hallmark of B-CLL cells. B-CLL cells are activated cells and their ZAP-70 expression reflects a normal property of activated B cells populations rather than a neoplastic aberration.
语言:: eng
DOI:: 10.1002/eji.200526355

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