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PMID: 1645800 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

v-myb and v-ets cooperate for the mitogenic stimulation of primary fibroblasts by avian E26 retrovirus.

Journal of virology ·Vol. 65 ·No. 7 ·1991-07-00 ·Pages 3928-31

Ravel-Chapuis P, Leprince D, Pain B, Li R, Domenget C, Stehelin D, Samarut J, Jurdic P

Abstract

By using a series of deletion mutants, we have shown that the stimulation of fibroblast growth by E26 requires the cooperation of the two oncogenes, v-myb and v-ets, fused in the nuclear viral product. Of the two DNA-binding domains, only one must be present to promote anchorage-independent growth, whereas that of v-myb is required to allow growth in low serum medium. Furthermore, the v-ets oncogene comprises multifunctional domains.

MeSH Terms
Animals Avian Leukosis Virus/genetics Cell Division Cells, Cultured Chick Embryo DNA Mutational Analysis DNA-Binding Proteins/physiology In Vitro Techniques Nuclear Proteins/physiology Oncogene Proteins v-myb Restriction Mapping Retroviridae Proteins, Oncogenic/genetics Structure-Activity Relationship
Chemicals
DNA-Binding Proteins Nuclear Proteins Oncogene Proteins v-myb Retroviridae Proteins, Oncogenic oncogene proteins v-ets
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Ravel-Chapuis P
Laboratoire de Biologie Moléculaire et Cellulaire, UMR 13 CNRS, Institut National de la Recherche Agronomique, Ecole Normale Supérieure de Lyon, France.
Leprince D
Pain B
Li R
Domenget C
Stehelin D
Samarut J
Jurdic P
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28 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.65.7.3928-3931.1991
Published
1991-07-00
Pages
3928-31
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC241431
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.65.7.3928-3931.1991 PMC Full Text View journal details
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