Home LiteratureArticle Details
PMID: 1645125 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A dominant mutation in the gene for the Nag repressor of Escherichia coli that renders the nag regulon uninducible.

Journal of general microbiology ·Vol. 138 ·No. 5 ·1992-05-00 ·Pages 1011-7

Plumbridge JA

Abstract

The gene nagC encodes the repressor for the nag regulon. A point mutation within the gene, which confers a super-repressor phenotype and makes the repressor insensitive to the inducer, N-acetylglucosamine 6-phosphate, has been characterized. The mutation is semi-dominant since heterozygous diploids have reduced growth rates on glucosamine and N-acetylglucosamine compared to the wild-type strain.

Related Genes
nagC
MeSH Terms
Acetylglucosamine/analogs & derivatives,metabolism Amidohydrolases/biosynthesis,genetics Amino Acyl-tRNA Synthetases/genetics Bacterial Proteins/genetics Chromosome Mapping Cloning, Molecular Diploidy Enzyme Induction/genetics Escherichia coli/genetics Escherichia coli Proteins Gene Expression Regulation, Bacterial Genes, Dominant/genetics Glucosamine/metabolism Mutation/genetics Recombinant Fusion Proteins/biosynthesis Repressor Proteins/genetics Transcription Factors Transduction, Genetic beta-Galactosidase/biosynthesis
Chemicals
Bacterial Proteins Escherichia coli Proteins Recombinant Fusion Proteins Repressor Proteins Transcription Factors nagC protein, E coli N-acetylglucosamine 6-phosphate beta-Galactosidase Amidohydrolases N-acetylglucosamine-6-phosphate deacetylase Amino Acyl-tRNA Synthetases glutaminyl-tRNA synthetase Glucosamine Acetylglucosamine
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Plumbridge J A
Institut de Biologie Physico-chimique (URA1139), Paris, France.
Article Info
Journal
Journal of general microbiology
Abbr.
J Gen Microbiol
ISSN
0022-1287
DOI
10.1099/00221287-138-5-1011
Published
1992-05-00
Pages
1011-7
Language
English
Region
England
NLM ID
0375371
Subset
IM
External Links
PubMed source DOI: 10.1099/00221287-138-5-1011
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2