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PMID: 164502 Published · ppublish English Journal Article

Respiratory and humoral immune response to aerosol and intramuscular pertussis vaccine.

The Journal of hygiene ·Vol. 74 ·No. 2 ·1975-04-00 ·Pages 233-7

Thomas G

Abstract

Animal experiments have shown that respiratory administration of pertussis antigen induces a protective immune response. In this study pertussis antibody in human respiratory secretions was measured and the response to aerosol and intramuscular pertussis immunization investigated. Substanial increases in this antibody occurred after aerosol immunization but no changes were found in serum antibody. The reverse was observed after intramuscular pertussis vaccine in adults but not with aerosol immunization. The latter method may be of value for paediatric medical and nursing personnel exposed to the risk of pertussis infection.

MeSH Terms
Aerosols Antibodies, Bacterial/analysis Antibody Formation Bordetella pertussis/immunology Hemagglutination Tests Humans Immunoglobulin A/analysis Injections, Intramuscular Nasal Mucosa/immunology,metabolism Pertussis Vaccine/administration & dosage Radioimmunoassay
Chemicals
Aerosols Antibodies, Bacterial Immunoglobulin A Pertussis Vaccine
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Thomas G
References (9)
9 references, click to expand
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Article Info
Journal
The Journal of hygiene
Abbr.
J Hyg (Lond)
ISSN
0022-1724
DOI
10.1017/s0022172400024293
Published
1975-04-00
Pages
233-7
Language
English
Region
England
NLM ID
0375374
PMCID
PMC2130377
Subset
IM
External Links
PubMed source DOI: 10.1017/s0022172400024293 PMC Full Text View journal details
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