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题目:: Genomic imbalances and patterns of karyotypic variability in mantle-cell lymphoma cell lines.
作者:: Camps(Jordi),Salaverria(Itziar),Garcia(Maria J),Prat(Esther),Beà(Sílvia),Pole(Jessica C),Hernández(Lluis),Del Rey(Javier),Cigudosa(Juan Cruz),Bernués(Marta),Caldas(Carlos),Colomer(Dolors),Miró(Rosa),Campo(Elías)
状态:: 发布时间2006-06-12 , 更新时间 2006-06-12
期刊:: Leuk Res
摘要:: Mantle-cell lymphoma (MCL) is genetically characterized by 11q13 chromosomal translocations involving the CCND1 gene. We have characterized five MCL cell lines, JVM-2, GRANTA-519, REC-1, JEKO-1, and NCEB-1, combining metaphase and array comparative genomic hybridization, multicolor-FISH, and molecular analysis. Our results revealed common gained regions at 2p14, 9q31.2-qter, 11q13.1-q21, 13q14-q21.2, 13q34-qter and 18q21.1-q22.1, and losses at 1p21.2-p31.1, 2p11.2, 8p21.2-pter, 9p21.3-pter, 11q23.3-qter, 17p11.2-pter, and 17q21.2-q22.2. All cell lines except JVM-2, displayed moderate or high numerical chromosome instability. In addition, an ongoing level of chromosome rearrangements was observed in REC-1. Surprisingly, NCEB-1 carried several stable mouse chromosomes and showed expression of both human and murine bcl-2 protein. Our findings indicate that these cell lines represent three patterns of chromosome evolution in MCL and may be useful to understand the pathogenesis of this neoplasm.
语言:: eng
DOI:: 10.1016/j.leukres.2005.11.013

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