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PMID: 16443334 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The testis-specific apoptosis related gene TTL.6 underwent adaptive evolution in the lineage leading to humans.

Gene ·Vol. 370 ·2006-03-29 ·Pages 58-63

Chen XH, Shi H, Liu XL, Su B

Abstract

The TTL.6 gene is a member of the tubulin-tyrosine ligase (TTL) family involved in apoptosis and preferentially expressed in the testis. We sequenced the coding region and part of the introns of TTL.6 in world wide human populations and five representative nonhuman primate species covering great apes, lesser ape and Old World monkey. The sequence substitution patterns of TTL.6 in primates demonstrated a sharp difference in evolutionary rates among different primate lineages. Our results indicated an accelerated evolution of TTL.6 in the human lineage, which was caused by Darwinian positive selection. Further analysis on sequence variations in human populations demonstrated an excess of derived common alleles, which was likely caused by genetic hitchhiking, an implication of recent positive selection on TTL.6 in human populations.

MeSH Terms
Alleles Animals Apoptosis/genetics Base Sequence Evolution, Molecular Gene Expression Regulation/physiology Genetic Variation Hominidae/genetics,metabolism Humans Male Molecular Sequence Data Organ Specificity/physiology Peptide Synthases/biosynthesis,genetics Selection, Genetic Testis/metabolism
Chemicals
Peptide Synthases TTLL6 protein, human tyrosyltubulin ligase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Chen Xiao-hua
Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, The Chinese Academy of Sciences (CAS), Kunming, China.
Shi Hong
Liu Xiao-Lin
Su Bing
Article Info
Journal
Gene
Abbr.
Gene
ISSN
0378-1119
Published
2006-03-29
Epub
2006-00-27
Pages
58-63
Language
English
Region
Netherlands
NLM ID
7706761
Subset
IM
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