Home LiteratureArticle Details
PMID: 16439620 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Large-scale sequence analysis of avian influenza isolates.

Science (New York, N.Y.) ·Vol. 311 ·No. 5767 ·2006-03-17 ·Pages 1576-80

Obenauer JC, Denson J, Mehta PK, Su X, Mukatira S, Finkelstein DB, Xu X, Wang J, Ma J, Fan Y, Rakestraw KM, Webster RG, Hoffmann E, Krauss S, Zheng J, Zhang Z, Naeve CW

Abstract

The spread of H5N1 avian influenza viruses (AIVs) from China to Europe has raised global concern about their potential to infect humans and cause a pandemic. In spite of their substantial threat to human health, remarkably little AIV whole-genome information is available. We report here a preliminary analysis of the first large-scale sequencing of AIVs, including 2196 AIV genes and 169 complete genomes. We combine this new information with public AIV data to identify new gene alleles, persistent genotypes, compensatory mutations, and a potential virulence determinant.

MeSH Terms
Animals Birds/virology Computational Biology Genes, Viral Genome, Viral Humans Influenza A Virus, H1N1 Subtype/genetics Influenza A Virus, H2N2 Subtype/genetics Influenza A Virus, H3N2 Subtype/genetics Influenza A Virus, H3N8 Subtype/genetics Influenza A Virus, H5N1 Subtype/chemistry,genetics,pathogenicity Influenza A Virus, H5N2 Subtype/genetics Influenza A Virus, H7N7 Subtype/genetics Influenza A Virus, H9N2 Subtype/genetics Influenza A virus/chemistry,genetics,isolation & purification,pathogenicity Influenza in Birds/virology Influenza, Human/virology Molecular Sequence Data Mutation Phylogeny RNA, Viral/genetics Reassortant Viruses/genetics Sequence Analysis, DNA Viral Nonstructural Proteins/chemistry,genetics Viral Proteins/chemistry,genetics Virulence Factors/chemistry,genetics
Chemicals
INS1 protein, influenza virus RNA, Viral Viral Nonstructural Proteins Viral Proteins Virulence Factors
Authors & Affiliations
17 authors, click to expand affiliations / ORCID
Obenauer John C
Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Denson Jackie
Mehta Perdeep K
Su Xiaoping
Mukatira Suraj
Finkelstein David B
Xu Xiequn
Wang Jinhua
Ma Jing
Fan Yiping
Rakestraw Karen M
Webster Robert G
Hoffmann Erich
Krauss Scott
Zheng Jie
Zhang Ziwei
Naeve Clayton W
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
Published
2006-03-17
Epub
2006-00-26
Pages
1576-80
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Grants
NIGMS NIH HHS · R01 GM061739 · United States
NIGMS NIH HHS · R01 GM069916 · United States
NIAID NIH HHS · AI95357 · United States
NCI NIH HHS · CA 21765 · United States
Databases
GENBANK
CY003847, CY003848, CY003849, CY003850, CY003851, CY003852, CY003853, CY003854, CY003855, CY003856, CY003857, CY003858, CY003859, CY003860, CY003861, CY003862, CY003863, CY003864, CY003865, CY003866, CY003867, CY003868, CY003869, CY003870, CY003871, CY003872, CY003873, CY003874, CY003875, CY003876, CY003877, CY003878, CY003879, CY003880, CY003881, CY003882, CY003883, CY003884, CY003885, CY003886, CY003887, CY003888, CY003889, CY003890, CY003891, CY003892, CY003893, CY003894, CY003895, CY003896, CY003897, CY003898, CY003899, CY003900, CY003901, CY003902, CY003903, CY003904, CY003905, CY003906, CY003907, CY003908, CY003909, CY003910, CY003911, CY003912, CY003913, CY003914, CY003915, CY003916, CY003917, CY003918, CY003919, CY003920, CY003921, CY003922, CY003923, CY003924, CY003925, CY003926, CY003927, CY003928, CY003929, CY003930, CY003931, CY003932, CY003933, CY003934, CY003935, CY003936, CY003937, CY003938, CY003939, CY003940, CY003941, CY003942, CY003943, CY003944, CY003945, CY003946, CY003947, CY003948, CY003949, CY003950, CY003951, CY003952, CY003953, CY003954, CY003955, CY003956, CY003957, CY003958, CY003959, CY003960, CY003961, CY003962, CY003963, CY003964, CY003965, CY003966, CY003967, CY003968, CY003969, CY003970, CY003971, CY003972, CY003973, CY003974, CY003975, CY003976, CY003977, CY003978, CY003979, CY003980, CY003981, CY003982, CY003983, CY003984, CY003985, CY003986, CY003987, CY003988, CY003989, CY003990, CY003991, CY003992, CY003993, CY003994, CY003995, CY003996, CY003997, CY003998, CY003999, CY004000, CY004001, CY004002, CY004003, CY004004, CY004005, CY004006, CY004007, CY004008, CY004009, CY004010, CY004011, CY004012, CY004013, CY004014, CY004015, CY004016, CY004017, CY004018, CY004019, CY004020, CY004021, CY004022, CY004023, CY004024, CY004025, CY004026, CY004027, CY004028, CY004029, CY004030, CY004031, CY004032, CY004033, CY004034, CY004035, CY004036, CY004037, CY004038, CY004039, CY004040, CY004041, CY004042, CY004043, CY004044, CY004045, CY004046, CY004047, CY004048, CY004049, CY004050, CY004051, CY004052, CY004053, CY004054, CY004055, CY004056, CY004057, CY004058, CY004059, CY004060, CY004061, CY004062, CY004063, CY004064, CY004065, CY004066, CY004067, CY004068, CY004069, CY004070, CY004071, CY004072, CY004073, CY004074, CY004075, CY004076, CY004077, CY004078, CY004079, CY004080, CY004081, CY004082, CY004083, CY004084, CY004085, CY004086, CY004087, CY004088, CY004089, CY004090, CY004091, CY004092, CY004093, CY004094, CY004095, CY004096, CY004097, CY004098, CY004099, CY004100, CY004101, CY004102, CY004103, CY004104, CY004105, CY004106, CY004107, CY004108, CY004109, CY004110, CY004111, CY004112, CY004113, CY004114, CY004115, CY004116, CY004117, CY004118, CY004119, CY004120, CY004121, CY004122, CY004123, CY004124, CY004125, CY004126, CY004127, CY004128, CY004129, CY004130, CY004131, CY004132, CY004133, CY004134, CY004135, CY004136, CY004137, CY004138, CY004139, CY004140, CY004141, CY004142, CY004143, CY004144, CY004145, CY004146, CY004147, CY004148, CY004149, CY004150, CY004151, CY004152, CY004153, CY004154, CY004155, CY004156, CY004157, CY004158, CY004159, CY004160, CY004161, CY004162, CY004163, CY004164, CY004165, CY004166, CY004167, CY004168, CY004169, CY004170, CY004171, CY004172, CY004173, CY004174, CY004175, CY004176, CY004177, CY004178, CY004179, CY004180, CY004181, CY004182, CY004183, CY004184, CY004185, CY004186, CY004187, CY004188, CY004189, CY004190, CY004191, CY004192, CY004193, CY004194, CY004195, CY004196, CY004197, CY004198, CY004199, CY004200, CY004201, CY004202, CY004203, CY004204, CY004205, CY004206, CY004207, CY004208, CY004209, CY004210, CY004211, CY004212, CY004213, CY004214, CY004215, CY004216, CY004217, CY004218, CY004219, CY004220, CY004221, CY004222, CY004223, CY004224, CY004225, CY004226, CY004227, CY004228, CY004229, CY004230, CY004231, CY004232, CY004233, CY004234, CY004235, CY004236, CY004237, CY004238, CY004239, CY004240, CY004241, CY004242, CY004243, CY004244, CY004245, CY004246, CY004247, CY004248, CY004249, CY004250, CY004251, CY004252, CY004253, CY004254, CY004255, CY004256, CY004257, CY004258, CY004259, CY004260, CY004261, CY004262, CY004263, CY004264, CY004265, CY004266, CY004267, CY004268, CY004269, CY004270, CY004271, CY004272, CY004273, CY004274, CY004275, CY004276, CY004277, CY004278, CY004279, CY004280, CY004281, CY004282, CY004283, CY004284, CY004285, CY004286, CY004287, CY004288, CY004289, CY004290, CY004291, CY004292, CY004293, CY004294, CY004295, CY004296, CY004297, CY004298, CY004299, CY004300, CY004301, CY004302, CY004303, CY004304, CY004305, CY004306, CY004307, CY004308, CY004309, CY004310, CY004311, CY004312, CY004313, CY004314, CY004315, CY004316, CY004317, CY004318, CY004319, CY004320, CY004321, CY004322, CY004323, CY004324, CY004325, CY004326, CY004327, CY004328, CY004329, CY004330, CY004331, CY004332, CY004333, CY004334, CY004335, CY004336, CY004337, CY004338, CY004339, CY004340, CY004341, CY004342, CY004343, CY004344, CY004345, CY004346, CY004347, CY004348, CY004349, CY004350, CY004351, CY004352, CY004353, CY004354, CY004355, CY004356, CY004357, CY004358, CY004359, CY004360, CY004361, CY004362, CY004363, CY004364, CY004365, CY004366, CY004367, CY004368, CY004369, CY004370, CY004371, CY004372, CY004373, CY004374, CY004375, CY004376, CY004377, CY004378, CY004379, CY004380, CY004381, CY004382, CY004383, CY004384, CY004385, CY004386, CY004387, CY004388, CY004389, CY004390, CY004391, CY004392, CY004393, CY004394, CY004395, CY004396, CY004397, CY004398, CY004399, CY004400, CY004401, CY004402, CY004403, CY004404, CY004405, CY004406, CY004407, CY004408, CY004409, CY004410, CY004411, CY004412, CY004413, CY004414, CY004415, CY004416, CY004417, CY004418, CY004419, CY004420, CY004421, CY004422, CY004423, CY004424, CY004425, CY004426, CY004427, CY004428, CY004429, CY004430, CY004431, CY004432, CY004433, CY004434, CY004435, CY004436, CY004437, CY004438, CY004439, CY004440, CY004441, CY004442, CY004443, CY004444, CY004445, CY004446, CY004447, CY004448, CY004449, CY004450, CY004451, CY004452, CY004453, CY004454, CY004455, CY004456, CY004457, CY004458, CY004459, CY004460, CY004461, CY004462, CY004463, CY004464, CY004465, CY004466, CY004467, CY004468, CY004469, CY004470, CY004471, CY004472, CY004473, CY004474, CY004475, CY004476, CY004477, CY004478, CY004479, CY004480, CY004481, CY004482, CY004483, CY004484, CY004485, CY004486, CY004487, CY004488, CY004489, CY004490, CY004491, CY004492, CY004493, CY004494, CY004495, CY004496, CY004497, CY004498, CY004499, CY004500, CY004501, CY004502, CY004503, CY004504, CY004505, CY004506, CY004507, CY004508, CY004509, CY004510, CY004511, CY004512, CY004513, CY004514, CY004515, CY004516, CY004517, CY004518, CY004519, CY004520, CY004521, CY004522, CY004523, CY004524, CY004525, CY004526, CY004527, CY004528, CY004529, CY004530, CY004531, CY004532, CY004533, CY004534, CY004535, CY004536, CY004537, CY004538, CY004539, CY004540, CY004541, CY004542, CY004543, CY004544, CY004545, CY004546, CY004547, CY004548, CY004549, CY004550, CY004551, CY004552, CY004553, CY004554, CY004555, CY004556, CY004557, CY004558, CY004559, CY004560, CY004561, CY004562, CY004563, CY004564, CY004565, CY004566, CY004567, CY004568, CY004569, CY004570, CY004571, CY004572, CY004573, CY004574, CY004575, CY004576, CY004577, CY004578, CY004579, CY004580, CY004581, CY004582, CY004583, CY004584, CY004585, CY004586, CY004587, CY004588, CY004589, CY004590, CY004591, CY004592, CY004593, CY004594, CY004595, CY004596, CY004597, CY004598, CY004599, CY004600, CY004601, CY004602, CY004603, CY004604, CY004605, CY004606, CY004607, CY004608, CY004609, CY004610, CY004611, CY004612, CY004613, CY004614, CY004615, CY004616, CY004617, CY004618, CY004619, CY004620, CY004621, CY004622, CY004623, CY004624, CY004625, CY004626, CY004627, CY004628, CY004629, CY004630, CY004631, CY004632, CY004633, CY004634, CY004635, CY004636, CY004637, CY004638, CY004639, CY004640, CY004641, CY004642, CY004643, CY004644, CY004645, CY004646, CY004647, CY004648, CY004649, CY004650, CY004651, CY004652, CY004653, CY004654, CY004655, CY004656, CY004657, CY004658, CY004659, CY004660, CY004661, CY004662, CY004663, CY004664, CY004665, CY004666, CY004667, CY004668, CY004669, CY004670, CY004671, CY004672, CY004673, CY004674, CY004675, CY004676, CY004677, CY004678, CY004679, CY004680, CY004681, CY004682, CY004683, CY004684, CY004685, CY004686, CY004687, CY004688, CY004689, CY004690, CY004691, CY004692, CY004693, CY004694, CY004695, CY004696, CY004697, CY004698, CY004699, CY004700, CY004701, CY004702, CY004703, CY004704, CY004705, CY004706, CY004707, CY004708, CY004709, CY004710, CY004711, CY004712, CY004713, CY004714, CY004715, CY004716, CY004717, CY004718, CY004719, CY004720, CY004721, CY004722, CY004723, CY004724, CY004725, CY004726, CY004727, CY004728, CY004729, CY004730, CY004731, CY004732, CY004733, CY004734, CY004735, CY004736, CY004737, CY004738, CY004739, CY004740, CY004741, CY004742, CY004743, CY004744, CY004745, CY004746, CY004747, CY004748, CY004749, CY004750, CY004751, CY004752, CY004753, CY004754, CY004755, CY004756, CY004757, CY004758, CY004759, CY004760, CY004761, CY004762, CY004763, CY004764, CY004765, CY004766, CY004767, CY004768, CY004769, CY004770, CY004771, CY004772, CY004773, CY004774, CY004775, CY004776, CY004777, CY004778, CY004779, CY004780, CY004781, CY004782, CY004783, CY004784, CY004785, CY004786, CY004787, CY004788, CY004789, CY004790, CY004791, CY004792, CY004793, CY004794, CY004795, CY004796, CY004797, CY004798, CY004799, CY004800, CY004801, CY004802, CY004803, CY004804, CY004805, CY004806, CY004807, CY004808, CY004809, CY004810, CY004811, CY004812, CY004813, CY004814, CY004815, CY004816, CY004817, CY004818, CY004819, CY004820, CY004821, CY004822, CY004823, CY004824, CY004825, CY004826, CY004827, CY004828, CY004829, CY004830, CY004831, CY004832, CY004833, CY004834, CY004835, CY004836, CY004837, CY004838, CY004839, CY004840, CY004841, CY004842, CY004843, CY004844, CY004845, CY004846
Corrections
CommentIn
CommentIn
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com