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PMID: 16434666 Published · ppublish English Journal Article Randomized Controlled Trial Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG.

Neurology ·Vol. 66 ·No. 2 ·2006-01-24 ·Pages 250-2

Hersch SM, Gevorkian S, Marder K, Moskowitz C, Feigin A, Cox M, Como P, Zimmerman C, Lin M, Zhang L, Ulug AM, Beal MF, Matson W, Bogdanov M, Ebbel E, Zaleta A, Kaneko Y, Jenkins B, Hevelone N, Zhang H, Yu H, Schoenfeld D, Ferrante R, Rosas HD

Abstract

In a randomized, double-blind, placebo-controlled study in 64 subjects with Huntington disease (HD), 8 g/day of creatine administered for 16 weeks was well tolerated and safe. Serum and brain creatine concentrations increased in the creatine-treated group and returned to baseline after washout. Serum 8-hydroxy-2'-deoxyguanosine (8OH2'dG) levels, an indicator of oxidative injury to DNA, were markedly elevated in HD and reduced by creatine treatment.

MeSH Terms

8-Hydroxy-2'-Deoxyguanosine Adult Biological Availability Biomarkers/metabolism Brain/metabolism Creatine/adverse effects,pharmacokinetics,therapeutic use Deoxyguanosine/analogs & derivatives,antagonists & inhibitors,blood Double-Blind Method Female Humans Huntington Disease/blood,drug therapy,metabolism Male Middle Aged

Chemicals

Biomarkers 8-Hydroxy-2'-Deoxyguanosine Deoxyguanosine Creatine

Authors & Affiliations

24 authors, click to expand affiliations / ORCID

Hersch S M

Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. hersch@helix.mgh.harvard.edu

Gevorkian S

Marder K

Moskowitz C

Feigin A

Cox M

Como P

Zimmerman C

Lin M

Zhang L

Ulug A M

Beal M F

Matson W

Bogdanov M

Ebbel E

Zaleta A

Kaneko Y

Jenkins B

Hevelone N

Zhang H

Yu H

Schoenfeld D

Ferrante R

Rosas H D

Article Info

Journal

Neurology

Abbr.

Neurology

ISSN

1526-632X

DOI

10.1212/01.wnl.0000194318.74946.b6

hersch@helix.mgh.harvard.edu

Published

2006-01-24

Pages

250-2

Language

English

Region

United States

NLM ID

0401060

Subset

Grants

NCCIH NIH HHS · AT00613 · United States

NCRR NIH HHS · M01-RR00645 · United States

NCRR NIH HHS · M01-RR01066 · United States

NINDS NIH HHS · NS042861 · United States

NINDS NIH HHS · NS35255 · United States

External Links

PubMed source DOI: 10.1212/01.wnl.0000194318.74946.b6 View journal details

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Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG.

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