Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments.

Adult Age of Onset Aged Alzheimer Disease/genetics,metabolism Amino Acid Sequence Amyloid Precursor Protein Secretases Amyloid beta-Peptides/metabolism Amyloid beta-Protein Precursor/metabolism Amyloidosis, Familial/genetics,metabolism Aspartic Acid Endopeptidases Cell Compartmentation Down Syndrome/complications,genetics Endocytosis Endopeptidases/metabolism Endoplasmic Reticulum/metabolism Humans Membrane Microdomains Membrane Proteins/genetics,metabolism Middle Aged Molecular Sequence Data Plaque, Amyloid/metabolism Presenilin-1 Presenilin-2 Protein Processing, Post-Translational

Amyloid beta-Peptides Amyloid beta-Protein Precursor Membrane Proteins PSEN1 protein, human PSEN2 protein, human Presenilin-1 Presenilin-2 Amyloid Precursor Protein Secretases Endopeptidases Aspartic Acid Endopeptidases BACE1 protein, human