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PMID: 16428794 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Human tumor necrosis factor is a chemoattractant for the parasite Entamoeba histolytica.

Infection and immunity ·Vol. 74 ·No. 2 ·2006-02-00 ·Pages 1407-11

Blazquez S, Zimmer C, Guigon G, Olivo-Marin JC, Guillén N, Labruyère E

Abstract

In an analysis of the molecular factors triggering amebiasis, we investigated the chemotaxis of Entamoeba histolytica toward tumor necrosis factor (TNF) in vitro, using quantitative imaging techniques. Our findings enabled us to propose a hitherto unknown role for TNF as a chemokinetic and chemoattractant agent for this parasite.

MeSH Terms
Animals Chemotactic Factors/physiology Chemotaxis Entamoeba histolytica/growth & development,pathogenicity,physiology Humans Image Processing, Computer-Assisted Tumor Necrosis Factor-alpha/physiology
Chemicals
Chemotactic Factors TNF protein, human Tumor Necrosis Factor-alpha
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Blazquez Samantha
Cell Biology of Parasitism Unit, INSERM U389, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France.
Zimmer Christophe
Guigon Ghislaine
Olivo-Marin Jean-Christophe
Guillén Nancy
Labruyère Elisabeth
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/IAI.74.2.1407-1411.2006
Published
2006-02-00
Pages
1407-11
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC1360330
Subset
IM
External Links
PubMed source DOI: 10.1128/IAI.74.2.1407-1411.2006 PMC Full Text View journal details
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