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PMID: 1641037 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

The gene lin-3 encodes an inductive signal for vulval development in C. elegans.

Nature ·Vol. 358 ·No. 6386 ·1992-08-06 ·Pages 470-6

Hill RJ, Sternberg PW

Abstract

The lin-3 gene is necessary for induction of the Caenorhabditis elegans vulva by the anchor cell. It encodes a molecule similar to epidermal growth factor and to transforming growth factor-alpha and acts through the epidermal growth factor receptor homologue let-23. Expression of lin-3 in the anchor cell stimulates vulval induction; lin-3 may encode the vulval inducing signal.

MeSH Terms

Amino Acid Sequence Animals Animals, Genetically Modified Base Sequence Caenorhabditis/embryology,genetics Caenorhabditis elegans Proteins Cloning, Molecular Disorders of Sex Development Embryonic Induction/genetics Epidermal Growth Factor/genetics Female Helminth Proteins/genetics Molecular Sequence Data Recombinant Fusion Proteins Stem Cells/physiology Vulva/embryology

Chemicals

Caenorhabditis elegans Proteins Helminth Proteins Recombinant Fusion Proteins Lin-3 protein, C elegans Epidermal Growth Factor

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Hill R J

Howard Hughes Medical Institute, California Institute of Technology, Pasadena 91125.

Sternberg P W

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/358470a0

Published

1992-08-06

Pages

470-6

Language

English

Region

England

NLM ID

0410462

Subset

Corrections

CommentIn

PMID: 1641034

External Links

PubMed source DOI: 10.1038/358470a0 View journal details

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The gene lin-3 encodes an inductive signal for vulval development in C. elegans.

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