Activation of IL-6 production by UV irradiation of blood mononuclear cells from patients with systemic lupus erythematosus.

Clinical and experimental immunology ·Vol. 89 ·No. 2 ·1992-08-00 ·Pages 251-4

Pelton BK, Hylton W, Denman AM

Abstract

Cultured mononuclear cells from patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and normal donors were assayed for their ability to secrete IL-6 both spontaneously and after exposure to UV light. Mononuclear cells from SLE, RA and atopic control patients produced IL-6 spontaneously, while those from normal donors did not. Spontaneous production of IL-6 occurred in the non-adherent cell population. UV light-induced IL-6 production was confined exclusively to the SLE patients and was present only in the macrophage/monocyte fraction. This stimulation was induced by wavelengths in the UVA, UVB but not the UVC portion of the spectrum. These results suggest that cytokine release may be involved in the exacerbations of SLE provoked by photosensitivity.

MeSH Terms

Humans Interleukin-6/biosynthesis Leukocytes, Mononuclear/metabolism,radiation effects Lupus Erythematosus, Systemic/etiology,metabolism Ultraviolet Rays/adverse effects

Chemicals

Interleukin-6

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Pelton B K

Division of Immunological Medicine, Northwick Park Hospital, Harrow, Middlesex, UK.

Hylton W

Denman A M

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25 references, click to expand

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Article Info

Journal

Clinical and experimental immunology

Abbr.

Clin Exp Immunol

ISSN

0009-9104

DOI

10.1111/j.1365-2249.1992.tb06940.x

Published

1992-08-00

Pages

251-4

Language

English

Region

England

NLM ID

0057202

PMCID

PMC1554444

Subset

External Links

PubMed source DOI: 10.1111/j.1365-2249.1992.tb06940.x PMC Full Text View journal details

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Activation of IL-6 production by UV irradiation of blood mononuclear cells from patients with systemic lupus erythematosus.

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