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PMID: 16386961 Published · ppublish English Case Reports Journal Article Research Support, Non-U.S. Gov't

Detailed kinetics of EBV-specific CD4+ and CD8+ T cells during primary EBV infection in a kidney transplant patient.

Clinical immunology (Orlando, Fla.) ·Vol. 119 ·No. 1 ·2006-04-00 ·Pages 16-20

Piriou ER, van Dort K, Weel JF, Bemelman FJ, Gamadia LE, van Oers MH, van Baarle D

Abstract

The etiology of infectious mononucleosis is poorly understood and usually detected many weeks after infection. Here, we present a unique case of primary symptomatic EBV infection after kidney transplantation, in whom we analyzed both EBV-specific CD4+ and CD8+ T cells in detail from the moment of infection up to latency. We show that EBV-specific T-cell responses in peripheral blood during primary EBV infection after kidney transplantation peaked early after the appearance of viral load, but well before onset of IM symptoms, suggesting that IM in this case is not caused by high numbers of CD8+ T cells per se but may be caused by lack of homing to lymph nodes or tonsils.

MeSH Terms

Adult Antigens/immunology CD4-Positive T-Lymphocytes/cytology,immunology,metabolism CD8-Positive T-Lymphocytes/cytology,immunology,metabolism DNA-Binding Proteins/immunology Epitopes, T-Lymphocyte/immunology Epstein-Barr Virus Infections/blood,immunology,virology Granzymes Herpesvirus 4, Human/immunology Humans Infectious Mononucleosis/blood,immunology,virology Interferon-gamma/metabolism Kidney Transplantation Kinetics Lymphocyte Activation/immunology Lymphocyte Count Male Membrane Glycoproteins/metabolism Perforin Pore Forming Cytotoxic Proteins Serine Endopeptidases/metabolism Serologic Tests Trans-Activators/immunology Viral Load Viral Proteins/immunology

Chemicals

Antigens BZLF1 protein, Herpesvirus 4, Human DNA-Binding Proteins Epitopes, T-Lymphocyte Membrane Glycoproteins Pore Forming Cytotoxic Proteins Trans-Activators Viral Proteins Perforin Interferon-gamma GZMB protein, human Granzymes Serine Endopeptidases

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Piriou Erwan R W A N

Department of Clinical Viro-Immunology, Sanquin Research at CLB, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

van Dort Karel

Weel Jan F L

Bemelman Frederike J

Gamadia Laila E

van Oers Marinus H J

van Baarle Debbie

Article Info

Journal

Clinical immunology (Orlando, Fla.)

Abbr.

Clin Immunol

ISSN

1521-6616

DOI

10.1016/j.clim.2005.11.009

Published

2006-04-00

Epub

2006-00-04

Pages

16-20

Language

English

Region

United States

NLM ID

100883537

Subset

External Links

PubMed source DOI: 10.1016/j.clim.2005.11.009 View journal details

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Detailed kinetics of EBV-specific CD4+ and CD8+ T cells during primary EBV infection in a kidney transplant patient.

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