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PMID: 16377712 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Lethal action of quinolones against a temperature-sensitive dnaB replication mutant of Escherichia coli.

Antimicrobial agents and chemotherapy ·Vol. 50 ·No. 1 ·2006-01-00 ·Pages 362-4

Zhao X, Malik M, Chan N, Drlica-Wagner A, Wang JY, Li X, Drlica K

Abstract

Inhibition of DNA replication in an Escherichia coli dnaB-22 mutant failed to block quinolone-mediated lethality. Inhibition of protein synthesis by chloramphenicol inhibited nalidixic acid lethality and, to a lesser extent, ciprofloxacin lethality in both dnaB-22 and wild-type cells. Thus, major features of quinolone-mediated lethality do not depend on ongoing replication.

MeSH Terms
Anti-Infective Agents/pharmacology Bacterial Proteins/genetics Chloramphenicol/pharmacology DNA Helicases/genetics DNA Replication/drug effects DnaB Helicases Escherichia coli/drug effects,genetics Mutation Quinolones/pharmacology Temperature
Chemicals
Anti-Infective Agents Bacterial Proteins Quinolones Chloramphenicol DNA Helicases DnaB Helicases
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Zhao Xilin
Public Health Research Institute, 225 Warren St., Newark, New Jersey 07103, USA.
Malik Muhammad
Chan Nymph
Drlica-Wagner Alex
Wang Jian-Ying
Li Xinying
Drlica Karl
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.50.1.362-364.2006
Published
2006-01-00
Pages
362-4
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC1346826
Subset
IM
Grants
NIAID NIH HHS · R01 AI035257 · United States
NIAID NIH HHS · AIO63431 · United States
PHS HHS · SI35257 · United States
External Links
PubMed source DOI: 10.1128/AAC.50.1.362-364.2006 PMC Full Text View journal details
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