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题目:: Expression of Musashi-1 in the rat stomach and changes during mucosal injury and restitution.
作者:: Nagata(Hiroshi),Akiba(Yasutada),Suzuki(Hidekazu),Okano(Hideyuki),Hibi(Toshifumi)
状态:: 发布时间2006-01-02 , 更新时间 2006-11-15
期刊:: FEBS Lett
摘要:: Musashi-1 is involved in maintenance of neural stem cells. In the rat stomach, we found some cells in the luminal compartment of the mucosa that stained positively for Musashi-1. These cells were distinct from other cells of epithelial lineage, except for parietal cells, and coexpressed HES5. The Musashi-1-positive cells exfoliated after damage, while Musashi-1 expression in neck cells were upregulated, and proliferating cells diminished before reappearing and increasing in number thereafter. We conclude that a subpopulation of parietal cells acts as a source of Musashi-1, which contributes to rapid re-epithelization by restoration of stem cells and regulation of cell differentiation.
语言:: eng
DOI:: 10.1016/j.febslet.2005.11.041

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