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PMID: 16336680 Published · epublish English Journal Article

Current views concerning the influences of murine hepatic endothelial adhesive and cytotoxic properties on interactions between metastatic tumor cells and the liver.

Comparative hepatology ·Vol. 4 ·2005-12-09 ·Pages 8

Wang HH, Qiu H, Qi K, Orr FW

Abstract

Substantial recent experimental evidence has demonstrated the existence of reciprocal interactions between the microvascular bed of a specific organ and intravascular metastatic tumor cells through expression of adhesion molecules and nitric oxide release, resulting in a significant impact upon metastatic outcomes. This review summarizes the current findings of adhesive and cytotoxic endothelial-tumor cell interactions in the liver, the inducibility, zonal distribution and sinusoidal structural influences on the hepatic endothelial regulatory functions, and the effects of these functions on the formation of liver cancer metastases. New insights into the traditional cancer metastatic cascade are also discussed.

Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Wang Hui Helen
Department of Health Sciences, Red River College and Department of Pathology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. wangh0@cc.umanitoba.ca
Qiu Hongming
Qi Ke
Orr F William
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Article Info
Journal
Comparative hepatology
Abbr.
Comp Hepatol
ISSN
1476-5926
DOI
10.1186/1476-5926-4-8
Email
wangh0@cc.umanitoba.ca
Published
2005-12-09
Epub
2005-00-09
Pages
8
Language
English
Region
England
NLM ID
101147643
PMCID
PMC1334213
External Links
PubMed source DOI: 10.1186/1476-5926-4-8 PMC Full Text
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