Home LiteratureArticle Details
PMID: 163220 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Cell-mediated immunity to Herpes simplex in humans: lymphocyte cytotoxicity measured by 51-Cr release from infected cells.

Infection and immunity ·Vol. 11 ·No. 2 ·1975-02-00 ·Pages 355-9

Russell AS, Percy JS, Kovithavongs T

Abstract

We assessed cell-mediated immunity to herpes simplex virus type 1 antigen in patients suffering from recurrent cold sores and in a series of healthy controls. Paradoxically, all those subject to recurrent herpetic infections had, without exception, evidence of cell-mediated immunity to herpes antigens. This was demonstrated by lymphocyte transformation and specific 51Cr release from infected human amnion cells after incubation with peripheal blood mononuclear cells. Where performed, skin tests with herpes antigen were also positive. In addition, serum from these patients specifically sensitized herpesvirus-infected cells to killing by nonimmune, control mononuclear cells. These tests were negative in the control patients except in a few cases, and it is suggested that these latter may be the asymptomatic herpesvirus carriers previously recognized or that they may have experienced a genital infection.

MeSH Terms
Amnion Antibodies, Viral/analysis Antigens, Viral Binding Sites, Antibody Binding, Competitive Chromium Radioisotopes Complement Fixation Tests Complement System Proteins Culture Techniques Cytotoxicity Tests, Immunologic Humans Immunity, Cellular Immunoglobulin Fc Fragments Lymphocyte Activation Lymphocytes/immunology Simplexvirus/immunology Skin Tests Virus Cultivation
Chemicals
Antibodies, Viral Antigens, Viral Chromium Radioisotopes Immunoglobulin Fc Fragments Complement System Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Russell A S
Percy J S
Kovithavongs T
References (33)
33 references, click to expand
  1. Interferon levels and resistance to viral infection associated with selected interferon inducers.
    Proc Soc Exp Biol Med. 1971 Oct;138(1):317-21 PMID: 4331094
  2. Contactual lysis of antibody-coated chicken erythrocytes by purified lymphocytes.
    Cell Immunol. 1970 Sep;1(3):300-15 PMID: 5523583
  3. Viral infections in man associated with acquired immunological deficiency states.
    Fed Proc. 1971 Nov-Dec;30(6):1858-64 PMID: 4333313
  4. Use of the 51 Cr release test to demonstrate patterns of antibody response in humans to herpesvirus types 1 and 2.
    J Immunol. 1972 Sep;109(3):554-64 PMID: 4341272
  5. Prevention of cell-to-cell spread of herpes simplex virus by leukocytes.
    J Exp Med. 1973 Mar 1;137(3):706-20 PMID: 4347596
  6. Host defense mechanisms against herpes simplex virus. II. Protection conferred by sensitized spleen cells.
    J Infect Dis. 1973 Jun;127(6):632-8 PMID: 4350518
  7. Cell-mediated immunity to Varicella-Zoster antigen in acute Herpes zoster (shingles).
    Clin Exp Immunol. 1973 Jun;14(2):181-5 PMID: 4352254
  8. THE PATHOGENESIS OF HERPES VIRUS ENCEPHALITIS. II. A CELLULAR BASIS FOR THE DEVELOPMENT OF RESISTANCE WITH AGE.
    J Exp Med. 1964 Sep 1;120:359-74 PMID: 14207057
  9. Studies on herpes simplex virus. VI. Observations on patients with recurrent herpetic lesions injected with herpes viruses or their antigens.
    Am J Med Sci. 1955 May;229(5):477-85 PMID: 14361413
  10. An attempt to vaccinate against herpes simplex.
    Aust J Exp Biol Med Sci. 1950 Sep;28(5):579-84 PMID: 14820702
  11. Complement-fixing antigens of herpes simplex virus types 1 and 2: reactivity of capsid, envelope, and soluble antigens.
    Infect Immun. 1972 Feb;5(2):248-54 PMID: 4117881
  12. Rapid preparation of lymphocytes for tissue-typing.
    Lancet. 1969 Aug 9;2(7615):327 PMID: 4184246
  13. Immunity to tissue sensitisation, HL-A and non-HL-A, as detected by the ABCIL system.
    Transplantation. 1974 May;17(5):453-61 PMID: 4275076
  14. Recurrent herpes in the rabbit and man.
    Science. 1967 Jun 23;156(3782):1628-9 PMID: 4290539
  15. Significance of Herpesvirus hominis in respiratory secretions of man.
    N Engl J Med. 1968 Mar 7;278(10):517-23 PMID: 4295319
  16. Electron microscopy of herpes simplex virus. IV. Studies with ferritin-conjugated antibodies.
    J Virol. 1968 Oct;2(10):1172-84 PMID: 4302020
  17. A prospective study of chronic herpes simplex virus infection and recurrent herpes labialis in humans.
    J Immunol. 1970 Feb;104(2):289-95 PMID: 4312871
  18. Enhancement of virus multiplication and interferon production by cortisone in ocular herpesvirus infection.
    J Immunol. 1970 Jun;104(6):1359-63 PMID: 4315897
  19. Clinically evident, non-terminal infections with herpesviruses and the wart virus in immunosuppressed renal allograft recipients.
    Br Med J. 1970 Aug 1;3(5717):251-4 PMID: 4317670
  20. Recurrent viral infection (reinfection).
    N Engl J Med. 1971 Apr 8;284(14):765-73 PMID: 4323312
  21. Infection with herpes-simplex viruses 1 and 2. 3.
    N Engl J Med. 1973 Oct 11;289(15):781-9 PMID: 4353941
  22. Resistance of rabbit corneal epithelium to herpes simplex virus.
    N Y State J Med. 1973 Sep 1;73(17):2159-61 PMID: 4353944
  23. Pathogenetic studies of herpes simplex virus infection of the rabbit eye.
    Proc Soc Exp Biol Med. 1973 Nov;144(2):705-9 PMID: 4355761
  24. Cell-mediated immunity to herpes simplex virus in man.
    Am J Clin Pathol. 1973 Dec;60(6):826-30 PMID: 4357123
  25. Host defenses against viral disease.
    N Engl J Med. 1974 Feb 7;290(6):323-9 PMID: 4358448
  26. Cell-mediated immunity to herpes simplex virus in man.
    J Infect Dis. 1974 Feb;129(2):142-6 PMID: 4359402
  27. Lymphocyte interferon production and transformation after Herpes simplex infections in humans.
    J Immunol. 1974 Feb;112(2):728-36 PMID: 4360547
  28. Cell-mediated immunity in Herpesvirus hominis infections.
    Br Med J. 1972 Mar 18;1(5802):723-6 PMID: 4552465
  29. Lymphocyte mediators and cellular hypersensitivity.
    N Engl J Med. 1973 Jan 18;288(3):143-9 PMID: 4567414
  30. The effector cell in antibody-induced cell mediated immunity.
    Transplant Rev. 1973;17(0):108-49 PMID: 4600483
  31. Studies of allograft immunity in mice. I. Induction, development and in vitro assay of cellular immunity.
    Immunology. 1970 Apr;18(4):501-15 PMID: 4986975
  32. The activation of varicella-zoster virus infections by immunosuppressive therapy.
    J Lab Clin Med. 1966 Sep;68(3):463-74 PMID: 5332136
  33. Herpes Zoster-Varicella infections and lymphoma.
    Ann Intern Med. 1972 Feb;76(2):235-40 PMID: 4333227
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.11.2.355-359.1975
Published
1975-02-00
Pages
355-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC415070
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.11.2.355-359.1975 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2