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PMID: 16313355 Published · ppublish English Journal Article Review

Relationship between SPRY and B30.2 protein domains. Evolution of a component of immune defence?

Immunology ·Vol. 116 ·No. 4 ·2005-12-00 ·Pages 411-7

Rhodes DA, de Bono B, Trowsdale J

Abstract

SPRY and B30.2 are homologous domains which can be identified in 11 protein families encoded in the human genome. These include cell surface receptors of the immunoglobulin super-family (BTNs), negative regulators of the JAK/STAT pathway (SOCS-box SSB1-4) and proteins encoded by the numerous TRIM genes. Collectively, proteins containing SPRY and B30.2 domains cover a wide range of functions, including regulation of cytokine signalling (SOCS), RNA metabolism (DDX1, hnRNPs), intracellular calcium release (RyR receptors), immunity to retroviruses (TRIM5alpha) as well as regulatory and developmental processes (HERC1, Ash2L). In order to clarify the evolutionary relationship between the two domains, we compiled a curated database of SPRY and B30.2-domain sequences. We show that while SPRY domains are evolutionarily ancient, B30.2 domains, found in BTN and TRIM proteins, are a more recent evolutionary adaptation, comprising the combination of SPRY with an additional domain, PRY. The combination of SPRY and PRY to produce B30.2 domains may have been selected and maintained as a component of immune defence.

MeSH Terms
Amino Acid Sequence Animals Antiviral Restriction Factors Carrier Proteins/metabolism Evolution, Molecular HIV-1/metabolism Humans Immunity, Innate/genetics Molecular Sequence Data Protein Structure, Tertiary/genetics Sequence Alignment Tripartite Motif Proteins Ubiquitin-Protein Ligases
Chemicals
Antiviral Restriction Factors Carrier Proteins Tripartite Motif Proteins TRIM5 protein, human Ubiquitin-Protein Ligases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Rhodes David A
Cambridge Institute for Medical Research, Addensbrookes Hospital, Cambridge, UK. dar32@mole.bio.cam.ac.uk
de Bono Bernard
Trowsdale John
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Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
DOI
10.1111/j.1365-2567.2005.02248.x
Email
dar32@mole.bio.cam.ac.uk
Published
2005-12-00
Pages
411-7
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1802431
Subset
IM
Grants
Medical Research Council · G9800943 · United Kingdom
External Links
PubMed source DOI: 10.1111/j.1365-2567.2005.02248.x PMC Full Text View journal details
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