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题目:: The role of innate immune cells in the response of heat-treated Mycobacterium tuberculosis (M.tb) antigens stimulating PBMCs.
作者:: Wang(Chao),Li(Jun),Zheng(Huaixin),Wei(Haiming),Zhang(Ruijun),Li(Baiqing),Tian(Zhigang)
状态:: 发布时间2005-11-18 , 更新时间 2008-11-21
期刊:: Cell Mol Immunol
摘要:: The proliferation response of gammadelta T cells to the antigen from heat-treated Mycobacterium tuberculosis H37Ra (M.tb Ag) was used as a good model in gammadeltaT cell research. From preliminary research it is found that activated NK cells positively elevated gammadeltaT cells proliferation after simulating PBMCs with M.tb Ag. To investigate different behaviors of NK cells, gammadeltaNKT cells, gammadeltaT cells and relationships between these cell subsets, activation and proliferation of different cell subsets of PBMCs in response to M.tb Ag were analyzed. We demonstrated that NK cells, gammadeltaNKT cells and gammadeltaT cells could be activated after stimulation with M.tb Ag. gammadeltaNKT cells and gammadelta T cells proliferated while the number of NK cells decreased after 11 day-simulation with M.tb Ag. Meanwhile, at the early time of stimulation the cytotoxicity of PBMCs was enhanced.
语言:: eng
DOI:

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