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PMID: 16291697 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Iron-responsive regulation of biofilm formation in staphylococcus aureus involves fur-dependent and fur-independent mechanisms.

Journal of bacteriology ·Vol. 187 ·No. 23 ·2005-12-00 ·Pages 8211-5

Johnson M, Cockayne A, Williams PH, Morrissey JA

Abstract

We have shown that Staphylococcus aureus biofilm production is induced in iron-restricted conditions and is repressed by iron via a Fur-independent mechanism, while Fur has both positive and negative regulatory roles in low iron. Furthermore, there is no significant increase in polymeric N-acetylglucosamine polysaccharide expression to account for induction of biofilms in low iron.

MeSH Terms
Bacterial Proteins/genetics,metabolism Biofilms/growth & development Culture Media Gene Expression Regulation, Bacterial Iron Mutation Repressor Proteins/genetics,metabolism Staphylococcus aureus/genetics,physiology
Chemicals
Bacterial Proteins Culture Media Repressor Proteins ferric uptake regulating proteins, bacterial Iron
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Johnson Miranda
Department of Genetics, University of Leicester, UK. jam26@le.ac.uk.
Cockayne Alan
Williams Peter H
Morrissey Julie A
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21 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/JB.187.23.8211-8215.2005
Email
jam26@le.ac.uk
Published
2005-12-00
Pages
8211-5
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC1291266
Subset
IM
External Links
PubMed source DOI: 10.1128/JB.187.23.8211-8215.2005 PMC Full Text View journal details
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