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PMID: 1627654 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Primary sequence of -1436 to +53 bp of the rat preproenkephalin gene putative Z-DNA and regulatory motifs.

Biochimica et biophysica acta ·Vol. 1131 ·No. 3 ·1992-07-15 ·Pages 349-51

Durkin RC, Weisinger G, Holloway MP, La Gamma EF

Abstract

We report novel sequence data extending -1436 bases 5' of the rat proenkephalin gene start site known as E4. We noted an interesting stretch of 58 bases of alternating pyrimidines that lies immediately adjacent to 71 bases of an alternating purine-pyrimidine Z-DNA-like sequence that lies between -694 bp and -566 bp. Multiple sequence homologies to putative cis-acting regulatory factor binding sites were identified by a computer aided sequence search.

Related Genes

ppEnk

MeSH Terms

Animals Base Sequence Binding Sites/genetics DNA/genetics Enkephalins/genetics Gene Expression Regulation/genetics Molecular Sequence Data Protein Precursors/genetics Rats Regulatory Sequences, Nucleic Acid/genetics Sequence Homology, Nucleic Acid Transcription, Genetic/genetics

Chemicals

Enkephalins Protein Precursors DNA preproenkephalin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Durkin R C

Department of Pediatrics, SUNY, Stony Brook 11794.

Weisinger G

Holloway M P

La Gamma E F

Article Info

Journal

Biochimica et biophysica acta

Abbr.

Biochim Biophys Acta

ISSN

0006-3002

DOI

10.1016/0167-4781(92)90040-7

Published

1992-07-15

Pages

349-51

Language

English

Region

Netherlands

NLM ID

0217513

Subset

Databases

GENBANK

M80530, M80531, M80532, M80533, M91429, M91430, X59136, Z11855, Z11856, Z11902

External Links

PubMed source DOI: 10.1016/0167-4781(92)90040-7

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Primary sequence of -1436 to +53 bp of the rat preproenkephalin gene putative Z-DNA and regulatory motifs.

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