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PMID: 16261171 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S. Review

Deinococcus radiodurans - the consummate survivor.

Nature reviews. Microbiology ·Vol. 3 ·No. 11 ·2005-11-00 ·Pages 882-92

Cox MM, Battista JR

Abstract

Relatively little is known about the biochemical basis of the capacity of Deinococcus radiodurans to endure the genetic insult that results from exposure to ionizing radiation and can include hundreds of DNA double-strand breaks. However, recent reports indicate that this species compensates for extensive DNA damage through adaptations that allow cells to avoid the potentially detrimental effects of DNA strand breaks. It seems that D. radiodurans uses mechanisms that limit DNA degradation and that restrict the diffusion of DNA fragments that are produced following irradiation, to preserve genetic integrity. These mechanisms also increase the efficiency of the DNA-repair proteins.

MeSH Terms
DNA Repair DNA, Bacterial/radiation effects Deinococcus/genetics,radiation effects Phylogeny RNA, Bacterial/genetics RNA, Ribosomal, 16S/genetics Radiation Tolerance Radiation, Ionizing Rec A Recombinases/metabolism
Chemicals
DNA, Bacterial RNA, Bacterial RNA, Ribosomal, 16S Rec A Recombinases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cox Michael M
Department of Biochemistry, University of Wisconsin-Madison, Wisconsin 53706-1544, USA.
Battista John R
Article Info
Journal
Nature reviews. Microbiology
Abbr.
Nat Rev Microbiol
ISSN
1740-1526
Published
2005-11-00
Pages
882-92
Language
English
Region
England
NLM ID
101190261
Subset
IM
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