| GeneLibs

题目:: Expression of Nanog gene promotes NIH3T3 cell proliferation.
作者:: Zhang(Jingyu),Wang(Xia),Chen(Bing),Suo(Guangli),Zhao(Yanhong),Duan(Ziyuan),Dai(Jianwu)
状态:: 发布时间2005-11-15 , 更新时间 2016-11-24
期刊:: Biochem Biophys Res Commun
摘要:: Cells are the functional elements in tissue engineering and regenerative medicine. A large number of cells are usually needed for these purposes. However, there are numbers of limitations for in vitro cell proliferation. Nanog is an important self-renewal determinant in embryonic stem cells. However, it remains unknown whether Nanog will influence the cell cycle and cell proliferation of mature cells. In this study, we expressed Nanog in NIH3T3 cells and showed that expression of Nanog in NIH3T3 promoted cells to enter into S phase and enhanced cell proliferation. This suggests that Nanog gene might function in a similar fashion in mature cells as in ES cells. In addition, it may provide an approach for in vitro cell expansion.
语言:: eng
DOI:: 10.1016/j.bbrc.2005.10.071

文献库文献相关信息