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PMID: 16258538 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Platelets mediate cytotoxic T lymphocyte-induced liver damage.

Nature medicine ·Vol. 11 ·No. 11 ·2005-11-00 ·Pages 1167-9

Iannacone M, Sitia G, Isogawa M, Marchese P, Castro MG, Lowenstein PR, Chisari FV, Ruggeri ZM, Guidotti LG

Abstract

We found that platelet depletion reduces intrahepatic accumulation of virus-specific cytotoxic T lymphocytes (CTLs) and organ damage in mouse models of acute viral hepatitis. Transfusion of normal but not activation-blocked platelets in platelet-depleted mice restored accumulation of CTLs and severity of disease. In contrast, anticoagulant treatment that prevented intrahepatic fibrin deposition without reducing platelet counts did not avert liver injury. Thus, activated platelets contribute to CTL-mediated liver immunopathology independently of procoagulant function.

MeSH Terms
Animals Blood Platelets/metabolism Cell Count Cytotoxicity, Immunologic/genetics Disease Models, Animal Hepatitis B/immunology Hepatitis B virus/immunology Liver/immunology,pathology,virology Liver Diseases/immunology,pathology Mice Mice, Inbred C57BL Mice, Transgenic Platelet Activation Severity of Illness Index T-Lymphocytes, Cytotoxic/immunology
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Iannacone Matteo
Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Sitia Giovanni
Isogawa Masanori
Marchese Patrizia
Castro Maria G
Lowenstein Pedro R
Chisari Francis V
Ruggeri Zaverio M
Guidotti Luca G
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12 references, click to expand
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Article Info
Journal
Nature medicine
Abbr.
Nat Med
ISSN
1078-8956
DOI
10.1038/nm1317
Published
2005-11-00
Epub
2005-00-30
Pages
1167-9
Language
English
Region
United States
NLM ID
9502015
PMCID
PMC2908083
Subset
IM
Grants
NINDS NIH HHS · R01 NS054193 · United States
NINDS NIH HHS · R01 NS042893-01A1 · United States
NINDS NIH HHS · R01 NS061107-01A1 · United States
NINDS NIH HHS · U01 NS052465-01A2 · United States
NINDS NIH HHS · R21 NS054143-01A2 · United States
NINDS NIH HHS · U01 NS052465 · United States
NHLBI NIH HHS · HL31950 · United States
NINDS NIH HHS · R01 NS061107 · United States
NCI NIH HHS · R37 CA040489 · United States
NINDS NIH HHS · R01 NS054193-01A1 · United States
NINDS NIH HHS · R01 NS057711-01A2 · United States
NCI NIH HHS · CA40489 · United States
NHLBI NIH HHS · R37 HL042846 · United States
NHLBI NIH HHS · R01 HL042846 · United States
NINDS NIH HHS · R01 NS042893 · United States
NCI NIH HHS · R01 CA040489 · United States
NHLBI NIH HHS · P01 HL031950 · United States
NHLBI NIH HHS · HL42846 · United States
NINDS NIH HHS · R01 NS057711 · United States
NIAID NIH HHS · R01 AI040696 · United States
NHLBI NIH HHS · P01 HL078784 · United States
NHLBI NIH HHS · HL78784 · United States
NIAID NIH HHS · AI40696 · United States
NINDS NIH HHS · R21 NS054143 · United States
External Links
PubMed source DOI: 10.1038/nm1317 PMC Full Text View journal details
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