ADAM and Eph: how Ephrin-signaling cells become detached.
作者:
Mancia(Filippo),Shapiro(Lawrence)
状态:
发布时间2005-10-21
, 更新时间 2016-11-24
期刊:
Cell
摘要:
Ephrin ligands presented on one cell surface associate with their receptors on the surface of a juxtaposed cell, often resulting in cell-cell repulsion. In this issue of Cell, Janes et al. (2005) show that the ephrin ligand can be proteolytically released from its membrane tether by a complex on the opposing cell composed of the ephrin receptor and an ADAM metalloprotease.