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题目:: No association of the MDM2 SNP309 polymorphism with risk of breast or ovarian cancer.
作者:: Campbell(Ian G),Eccles(Diana M),Choong(David Y H)
状态:: 发布时间2006-07-31 , 更新时间 2016-11-24
期刊:: Cancer Lett
摘要:: A functional T to G germline polymorphism in the promoter region of MDM2 (SNP309) has been reported to profoundly accelerate tumor formation suggesting that it may also represent a powerful cancer predisposing allele. To investigate the role of SNP309 in cancer predisposition we undertook a case-control study of this polymorphism among 351 women diagnosed with breast cancer, 302 women diagnosed with ovarian and 258 female controls from a British population. The GG genotype was not associated with either breast cancer (OR 1.04, 95% CI 0.67-1.60) or ovarian cancer (OR 0.86, 95% CI 0.53-1.37). This study has found no evidence that the GG genotype of the MDM2 SNP309 polymorphism is associated with early onset or familial breast cancer or with ovarian cancer.
语言:: eng
DOI:: 10.1016/j.canlet.2005.09.003

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